- Synthesis of arylated and aminated naphthalenes and their synthetic applications for aza-heterocycles
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We have developed a new, metal free methodology for the synthesis of 3,4-diamino-2-methylsulfanyl-naphthalene-1-carbonitrile by reaction of 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile and nitromethane under basic conditions followed by reduction of n
- Singh, Surjeet,Shaw, Ranjay,Shally,Chaudhary, Sandeep,Kumar, Abhinav,Pratap, Ramendra
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- Synthesis of Partially Reduced Imidazo[1,2- a ]pyridines through an Unprecedented Base-Mediated (4+2) Cyclization
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A water-mediated regioselective synthesis of 6,7-diaryl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-a]pyridine-6-carbonitriles was performed by the reaction of 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile with 1-aryl-2-(imidazolidin-2-ylidene)ethanones un
- Panwar, Rahul,Singh, Surjeet,Yadav, Pratik,Shaw, Ranjay,Kumar, Abhinav,Pratap, Ramendra
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p. 819 - 824
(2017/04/06)
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- Synthesis of 1-amino-2-aroyl/acetylnaphthalenes through a base mediated one pot inter and intramolecular C-C bond formation strategy
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A new precursor 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile has been synthesized by the reaction of 2-cyanomethylbenzonitrile, carbon disulfide and methyl iodide under basic conditions. The reaction of 2-(1-cyano-2,2- bis(methylthio)vinyl)benzonitrile with various functionalized aryl/heteroaryl methyl ketones or acetone under basic conditions afforded 4-amino-3-aroyl/ heteroaroyl/acetyl-2-methylsulfanylnaphthalene-1-carbonitriles in good yields through a (5C + 1C) annulation strategy; this involves sequential intermolecular, followed by intramolecular, C-C bond formation reactions. The structure of the product was confirmed by single crystal X-ray crystallography. This journal is
- Singh, Surjeet,Yadav, Pratik,Sahu, Satya Narayan,Althagafi, Ismail,Kumar, Abhinav,Kumar, Brijesh,Ram, Vishnu Ji,Pratap, Ramendra
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p. 4730 - 4737
(2014/06/24)
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