161832-74-2

Basic information

• Product Name: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL
• Synonyms: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL;(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYLPENTAN-1-OL;(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL, 98% (99% EE/HPLC)
• CAS NO: 161832-74-2
• Molecular Formula: C₁₈H₂₃NO
• Molecular Weight: 269.38
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 161832-74-2.mol

Chemical Properties

• Melting Point: 144-147 °C(lit.)
• Boiling Point: 436.6 ºC at 760 mmHg
• Flash Point: 48 °C
• Appearance: /
• Density: 1.059 g/cm³
• Vapor Pressure: 2.14E-08mmHg at 25°C
• Refractive Index: 1.569
• PKA: 11.41±0.42(Predicted)
• CAS DataBase Reference: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL(161832-74-2)
• EPA Substance Registry System: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL(161832-74-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• Hazardous Substances Data: 161832-74-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL is used as a key intermediate in the synthesis of various pharmaceuticals for its unique molecular structure and chiral properties, contributing to the development of new drugs with enhanced efficacy and selectivity.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL is used as a chiral building block for the design and synthesis of novel bioactive molecules, targeting specific biological pathways and receptors with improved pharmacological profiles.
Used in Drug Development:
(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL is employed in drug development as a chiral template to create enantiomerically pure compounds, which can exhibit different biological activities and reduce potential side effects associated with racemic mixtures.
Further research and studies are being conducted to explore the potential uses of (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL in the field of medicine, with a focus on its applications in drug design and the development of innovative therapeutic agents.

InChI:InChI=1/C18H23NO/c1-14(2)13-17(19)18(20,15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,14,17,20H,13,19H2,1-2H3/t17-/m1/s1

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Downstream Products

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Relevant articles and documents

Large-scale synthesis of Singh's catalyst in a one-pot procedure starting from proline

A practical one-pot procedure for the preparation of Singh's catalyst from either l-/d-proline or Boc-proline is described. The coupling partner, a chiral amino alcohol, can be prepared and used directly without purification from the corresponding amino acid ester. Moreover, a procedure for tert-butoxycarbonyl (Boc) group removal using concentrated HCl in MeOH-DCM was developed and utilized for the multigram-scale synthesis of Singh's catalyst.

Easy preparation of enantiopure C2-symmetrical aminoalcohols derived from m-xylylene diamine

The title compounds were prepared by condensation of isophthaldehyde with chiral amino alcohols or α-amino esters in three different ways depending on the substitution pattern. These methods are: for N-substituted amino alcohols, by reduction of the epime