Identification of Potent Ras Signaling Inhibitors by Pathway-Selective Phenotype-Based Screening
Blocking the path to cancer: Application of efficient strategy for a phenotype-based screening of compound libraries to a library of sulindac-derived compounds (see scheme) yielded new inhibitors of the tumor-relevant Ras signal transduction pathway with high fidelity (as shown by microscopy). The results underline the advantage of using biologically prevalidated compound classes in chemical biology research.
Mueller, Oliver,Gourzoulidou, Eleni,Carpintero, Mercedes,Karaguni, Ioanna-Maria,Langerak, Anette,Herrmann, Christian,Moeroey, Tarik,Klein-Hitpass, Ludger,Waldmann, Herbert
p. 450 - 454
(2007/10/03)
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