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2-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE, with the chemical formula C8H4ClF3O2, is an acyl chloride characterized by a benzene ring with a trifluoromethoxy group and a carbonyl chloride group. It is a highly reactive chemical compound that is widely utilized in organic synthesis, particularly for the preparation of pharmaceuticals and agrochemicals.

162046-61-9

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162046-61-9 Usage

Uses

Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE is used as a reagent for the synthesis of various pharmaceutical compounds. Its high reactivity allows it to participate in a range of chemical reactions, such as acylation and nucleophilic substitution, which are crucial for the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE is employed as a reagent in the synthesis of agrochemicals. Its ability to undergo various chemical reactions contributes to the creation of effective compounds for agricultural applications.
Safety Precautions:
Due to the hazardous properties and high reactivity of 2-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE, it should be handled with extreme caution. It is essential to store it in a well-ventilated area, away from heat and moisture, to prevent any potential hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 162046-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,0,4 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 162046-61:
(8*1)+(7*6)+(6*2)+(5*0)+(4*4)+(3*6)+(2*6)+(1*1)=109
109 % 10 = 9
So 162046-61-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H4F3NO4/c9-8(10,11)5-2-1-4(7(13)14)3-6(5)12(15)16/h1-3H,(H,13,14)

162046-61-9 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (T2340)  2-(Trifluoromethoxy)benzoyl Chloride  >98.0%(GC)

  • 162046-61-9

  • 1g

  • 350.00CNY

  • Detail
  • TCI America

  • (T2340)  2-(Trifluoromethoxy)benzoyl Chloride  >98.0%(GC)

  • 162046-61-9

  • 5g

  • 1,120.00CNY

  • Detail
  • Alfa Aesar

  • (B23919)  2-(Trifluoromethoxy)benzoyl chloride, 97%   

  • 162046-61-9

  • 1g

  • 460.0CNY

  • Detail
  • Alfa Aesar

  • (B23919)  2-(Trifluoromethoxy)benzoyl chloride, 97%   

  • 162046-61-9

  • 5g

  • 1241.0CNY

  • Detail
  • Alfa Aesar

  • (B23919)  2-(Trifluoromethoxy)benzoyl chloride, 97%   

  • 162046-61-9

  • 25g

  • 4946.0CNY

  • Detail
  • Aldrich

  • (724556)  2-(Trifluoromethoxy)benzoyl chloride  98%

  • 162046-61-9

  • 724556-1G

  • 352.17CNY

  • Detail
  • Aldrich

  • (724556)  2-(Trifluoromethoxy)benzoyl chloride  98%

  • 162046-61-9

  • 724556-5G

  • 1,241.37CNY

  • Detail

162046-61-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE

1.2 Other means of identification

Product number -
Other names 2-trifluoromethoxybenzoic acid chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162046-61-9 SDS

162046-61-9Relevant articles and documents

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea against Meloidogyne incognita

Chang, Yaning,Zhang, Jingwei,Chen, Xiulei,Li, Zhong,Xu, Xiaoyong

supporting information, p. 2641 - 2644 (2017/05/10)

Two series of novel 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea were designed and synthesized. The bioassay results showed that most of the test compounds showed good nematicidal activity against M. incognita at the concentration of 10.0?mg?L?1 in vivo. The compounds A13, A17 and B3 showed excellent nematicidal activity on the second stage juveniles of the root-knot nematode with the inhibition rate of 51.3%, 58.3% and 51.3% at the concentration of 1.0?mg?L?1 respectively. It suggested that the structure of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea could be optimized further.

Design, synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold

Chen, Yin-Bo,Li, Ji-Ling,Shao, Xu-Sheng,Xu, Xiao-Yong,Li, Zhong

, p. 673 - 676 (2013/07/26)

A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized, in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned. The target compounds were characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm (Mythimna sepatara) at the concentration of 500 mg/L. Exhilaratingly, the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L. The difference in activities between the target compounds was influenced by the substituents, which provided some hints for further investigation on structure modifications.

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2, 1-a]isoindol-6(2H)-one, a selective, orally active agonist of the 5-HT 2C receptor

Wacker, Dean A.,Varnes, Jeffrey G.,Malmstrom, Sarah E.,Cao, Xueying,Hung, Chen-Pin,Ung, Thao,Wu, Ginger,Zhang, Ge,Zuvich, Eva,Thomas, Michael A.,Keim, William J.,Cullen, Mary Jane,Rohrbach, Kenneth W.,Qu, Qinling,Narayanan, Rangaraj,Rossi, Karen,Janovitz, Evan,Lehman-McKeeman, Lois,Malley, Mary F.,Devenny, James,Pelleymounter, Mary Ann,Miller, Keith J.,Robl, Jeffrey A.

, p. 1365 - 1379 (2007/10/03)

Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone- containing, selective 5-HT2C agonists as antiobesity agents. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a] isoindol-6(2H)-one (58), a 5-HT2C agonist with > 300-fold functional selectivity over 5-HT2B and > 70-fold functional selectivity over 5-HT2A. Oral dosing of 58 reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model.

Modulators of serotonin receptors

-

Page/Page column 21, (2010/02/11)

The present invention provides modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for exa

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