- TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS
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Disclosed are a series of compounds or their tautomers having a general structure represented by Formula (la), (lb), (Ila), (lIb), or (lIc) and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula (la), (lb), (Ila), (lIb), or (lIc) compounds or tautomers.
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Page/Page column 170; 171
(2021/04/23)
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- Conformational effects in the biological activity of fluorinated analogs of &β-thujaplicin
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Fluorination of β-thujaplicin with diethylaminosulfur trifluoride (DAST) gave 2-fluoro-4-isopropyltropone and 2-fluoro-6-isopropyltropone (1:1 mixture; 60percent).The relationships between the antibacterial activities and conformations of β-thujaplicin and its fluorinated analogs are discussed. - Keywords: Conformational effects; Biological activity; β-Thujaplicin; Fluorination; NMR spectroscopy; Semi-empirical MO calculations
- Murata, Kouichi,Kitazume, Tomoya
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p. 129 - 132
(2007/10/02)
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