162109-00-4

Basic information

• Product Name: 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,8-bromo-11-ethyl-5,11-dihydro-5-methyl-
• Synonyms: 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,8-bromo-11-ethyl-5,11-dihydro-5-methyl-;8-BroMo-11-ethyl-5-Methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one
• CAS NO: 162109-00-4
• Molecular Formula: C₁₄H₁₃BrN₄O
• Molecular Weight: 333.18
• Mol File: 162109-00-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,8-bromo-11-ethyl-5,11-dihydro-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,8-bromo-11-ethyl-5,11-dihydro-5-methyl-(162109-00-4)
• EPA Substance Registry System: 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one,8-bromo-11-ethyl-5,11-dihydro-5-methyl-(162109-00-4)

Safety Data

• Hazardous Substances Data: 162109-00-4(Hazardous Substances Data)

Upstream product

• 134698-42-3 5,11-dihydro-11-ethyl-8-bromo-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 74-88-4 methyl iodide 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 104612-36-4 5-bromo-2-hydroxynicotinic acid 
• 78686-86-9 5-bromo-2-chloro-pyridine-3-carbonyl chloride 

Downstream Products

• 607707-58-4 methyl 4-[2-(11-ethyl-5-methyl-6-oxo-6,11-dihydro-5H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-8-yl)ethoxy]-3-methylbenzoate 
• 607707-35-7 4-[2-(11-ethyl-6,11-dihydro-5-methyl-6-oxo-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-8-yl)ethoxy]-3-methylbenzoic acid 
• 607707-26-6 3-ethyl-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-2-yl)-ethoxy]-benzoic acid methyl ester 
• 211750-50-4 BIRK 122 
• 639469-45-7 C₂₃H₂₂N₄O₅S 

Relevant articles and documents

Development of a pilot-plant process for a nevirapine analogue HIV NNRT inhibitor

The pilot-plant synthesis of nevirapine analogue 1 is described. The compound was prepared in eight steps from substituted pyridine raw materials and 4-hydroxyquinoline. The key transformation involves a novel one-pot conversion of an arylhalide to arylac

Non-nucleoside reverse transcriptase inhibitors

Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

Non-nucleoside reverse transcriptase inhibitors

Provided are compounds of the general formula I: wherein R2 is selected from the group consisting of H, F, Cl, (C1-4) alkyl, (C3-4) cycloalkyl and CF3; R4 is H or Me; R5 is H, Me or Et, wit

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 3. Dipyrido[2,3-b:2',3'-e]diazepinones

We have explored the potential of derivatives of the dipyrido[2,3- b:2',3'-e][1,4]diazepinone ring system as inhibitors of HIV-1 reverse transcriptase (RT). These compounds are isomeric to the potent RT inhibitor nevirapine and are available via a novel Smiles rearrangement on intermediates used for the synthesis of nevirapine analogs. Derivatives of this isomeric series are weaker inhibitors of RT than corresponding nevirapine analogs, although with appropriate substitution of the A- and C- pyridine rings activity can be improved.