- Preparation method of 2-(methyl sulphonyl)-10H-phenothiazine
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The invention relates to a preparation method of 2-(methyl sulphonyl)-10H-phenothiazine and belongs to the technical field of medical intermediate preparation. According to the method, parachlorobenzenesulfonyl chloride and sodium salt of 2-bromothiophenol are taken as starting materials, two novel intermediates M1 and M3 not reported are involved, ideal schemes different from related references are explored in all experimental procedures, and particularly the cyclization process for synthesis of the final product 2-(methyl sulphonyl)-10H-phenothiazine completely breaks through various restrictions in literatures. The method has the advantages that the whole process is simple in step, convenient to operate, mild in reaction condition and easy to control, product yield in all the steps is high and the like, thereby being suitable for industrial production and having high value in use and social and economic benefits.
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