16224-24-1

Basic information

• Product Name: 1-Chloro-3-(hexyloxy)-2-propanol
• Synonyms: 1-Chloro-3-(hexyloxy)-2-propanol;2-Propanol, 1-chloro-3-(hexyloxy)-;Hexyl 3-chloro-2-hydroxy-N-propyl ether
• CAS NO: 16224-24-1
• Molecular Formula: C₉H₁₉ClO₂
• Molecular Weight: 194.699
• Mol File: 16224-24-1.mol

Chemical Properties

• Boiling Point: 274.5°Cat760mmHg
• Flash Point: 119.8°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.000683mmHg at 25°C
• Refractive Index: 1.45
• PKA: 13.29±0.20(Predicted)
• CAS DataBase Reference: 1-Chloro-3-(hexyloxy)-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3-(hexyloxy)-2-propanol(16224-24-1)
• EPA Substance Registry System: 1-Chloro-3-(hexyloxy)-2-propanol(16224-24-1)

Safety Data

• Hazardous Substances Data: 16224-24-1(Hazardous Substances Data)

Usage

Type of compound

Beta-adrenergic agonist

Usage

Bronchodilator in the treatment of asthma and other respiratory conditions

Mechanism of action

Relaxes smooth muscles in the airways, making breathing easier for individuals with respiratory issues

Side effects

Palpitations, tremors, anxiety

Health risks

Linked to cardiac arrhythmias

Current status

No longer widely used due to side effects and availability of safer and more effective medications for respiratory conditions

InChI:InChI=1/C9H19ClO2/c1-2-3-4-5-6-12-8-9(11)7-10/h9,11H,2-8H2,1H3

Upstream product

• 106-89-8 epichlorohydrin 
• 111-27-3 hexan-1-ol 

Downstream Products

• 10587-68-5 1-Hexyloxy-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol 
• 106972-45-6 hexyl glycerol 
• 5926-90-9 hexyloxymethyloxirane 

Relevant articles and documents

Synthesis of 1-alkoxy-3-N-succinimido-2-propanols

Procedures for preparing 1-alkoxy-3-chloro-2-propanols, with their subsequent transformation to 1-alkoxy-N-succinimido-2-propanols, were developed.

The kinetics of chloromethyloxirane reaction with alcohols and their adducts in the presence of stannic chloride

Rate constants of the reaction of chloromethyloxirane (epichlorohydrin) with methyl, n-propyl, isopropyl, n-, sec-, tert-butyl, n-hexyl, n-octyl, and n-decyl alcohols in the presence of stannic chloride were studied at 30, 40, and 50°C. Reaction is not first order in respect to epichlorohydrine and is particularly fast at the beginning and its rate constants are proportional to the concentration of the catalyst. The rate constants increase in the homologous series of C1-C10 alcohols. The reaction rates of 2-chloromethyloxirane with 1-chloromethyl-2-alkoxyethanols are ca. 2.5-times larger than that with corresponding alcohols.

Liquid-Liquid-Extraction of Metal Ions with Lariat Ethers

Lariat ethers of various ring size and substitution are synthesized and characterized by physical data and chemical analysis.The extraction behaviour of the crown compounds towards Na+, K+, Cs+ and Ag+ in a picric acid solution has been investigated.The extraction constants for 1:1 and 1:2 complexes are determined using the equilibrium distribution data.The results show that the flexible side chain in the investigated compounds has in no case a positive effect on the metal picrate extraction.