- Studies on reactions of 3-benzoyl-4-hydroxypyrido[3,2-e]-1,2-thiazines with primary amines and N-methylhydrazine
-
Reaction of the appropriate 3-benzoyl-4-hydroxypyrido[3,2-e]-1,2-thiazine- 1,1-dioxides 2 bearing a methyl or a 3-(4-arylpiperazin-1-yl)propyl group at the nitrogen atom of the thiazine ring with primary amines resulted in enamines of type (E)-3. The related products 8 were obtained by alkylation of 3-phenylpyrazolo[4,3-c]pyrido[3,2-e]-1,2-thiazine-5,5-dioxide 7 with the corresponding 1-aryl-4-(3-chloropropyl)piperazines 9. The structures of the new heterocycles 3 and 8, synthesized for pharmaceutical purposes, and of the model compounds 4-6, prepared for comparison of spectral properties, were proven through elemental, IR, 1H NMR and, in some cases (3d, 8a), X-ray data.
- Malinka,Karczmarzyk,Kaczmarz,Swiatek,Urbanczyk-Lipkowska
-
p. 815 - 829
(2007/10/03)
-
- Synthesis and pharmacological study of some derivatives of pyrazolo[4,3-c]-1,2-thiazine-5,5-dioxide, a novel heterocyclic ring system
-
Starting from pyridothiazines 1 and N-methyl(phenyl)hydrazines isomeric derivatives 2 and 3 of the pyrazolo[4,3-c]pyrido[3,2-e]-1,2-thiazine, a new heterocyclic ring system, have been obtained. The structure of the synthesized compounds was confirmed by s
- Malinka,Sieklucka-Dziuba,Rajtar-Cynke,Gasior,Kleinrok
-
-