Cyclization of 5-amino-1-aryl-1H-pyrazole-4-carbonitriles with β-dicarbonyl compounds
[Figure not available: see fulltext.] A method has been developed for the preparation of new pyrazolo[3,4-b]pyridines and tetrahydropyrazolo[3,4-b]quinolinones by the reactions of 5-amino-1-aryl-1H-pyrazole-4-carbonitriles with aliphatic and cyclic 1,3-di
Potapov, Andrei Yu.,Vandyshev, Dmitriy Yu.,Kosheleva, Yevgeniya A.,Polikarchuk, Vladimir A.,Potapov, Mikhail A.,Shikhaliev, Khidmet S.
Application of Nickel Complexes with 1,3-Dicarbonyl Compounds for Synthesis of Fused 4-Aminopyridine-Based Systems
Abstract: A potential of using nickel complexes with 1,3-dicarbonyl compounds for the transformation of heterocyclic aminonitriles into fused systems with a 4-aminopyridine core was evaluated. A possibility of introducing acidophobic groups into the molecules of fused compounds was shown.
Brovarets, V. S.,Panchishin, S. Ya.,Vydzhak, R. N.
p. 1439 - 1446
(2020/09/21)
Tin (IV) chloride-promoted one-pot synthesis of novel tacrine analogues
A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4- cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures o