Binding to large enzyme pockets: Small-molecule inhibitors of trypanothione reductase
The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on the flavoenzyme trypanothione reductase (TR). TR was ide
Persch, Elke,Bryson, Steve,Todoroff, Nickolay K.,Eberle, Christian,Thelemann, Jonas,Dirdjaja, Natalie,Kaiser, Marcel,Weber, Maria,Derbani, Hassan,Brun, Reto,Schneider, Gisbert,Pai, Emil F.,Krauth-Siegel, R. Luise,Diederich, Fran?ois
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p. 1880 - 1891
(2014/08/18)
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