The chemistry of the taxane diterpene: Stereoselective reductions of taxanes
Stereoselective reductions of taxanes are detailed. Chelation- controlled reductions employing SmI2 are described for the stereoselective reduction of the 9-keto functionality of the diterpene moiety of several taxanes. In all cases the 9β-hydr
Georg, Gunda I.,Harriman, Geraldine C. B.,Datta, Apurba,Ali, Syed,Cheruvallath, Zacharia,Dutta, Dinah,Vander Velde, David G.,Himes, Richard H.
p. 8926 - 8934
(2007/10/03)
Syntheses of Novel C-9 and C-10 Modified Bioactive Taxanes
A method has been developed for the syntheses of hitherto unreported C-9 and C-10 modified taxanes.These analogs demonstrated excellent to good cytotoxicity against B 16 melanoma cells.
Datta, Apurba,Velde, David G. Vander,Georg, Gunda I.
p. 1985 - 1988
(2007/10/02)
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