16277-06-8

Basic information

• Product Name: Proline, 2-methyl- (9CI)
• Synonyms: Proline, 2-methyl- (9CI);2-methylproline(SALTDATA: HCl);2-Methyl-DL-proline HCl
• CAS NO: 16277-06-8
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.15704
• Product Categories: GLYCINESCAFFOLD
• Mol File: 16277-06-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Proline, 2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 2-methyl- (9CI)(16277-06-8)
• EPA Substance Registry System: Proline, 2-methyl- (9CI)(16277-06-8)

Safety Data

• Hazardous Substances Data: 16277-06-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Proline, 2-methyl(9CI) is utilized as a building block in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their properties such as stability, bioavailability, or targeting specific biological pathways.
Used in Food Industry:
In the food industry, Proline, 2-methyl(9CI) may serve as a flavor enhancer or a component in the development of novel food additives. Its ability to interact with taste receptors could contribute to the creation of unique taste profiles or improve the overall flavor of food products.
Used in Chemical Industry:
Proline, 2-methyl(9CI) can be employed as an intermediate in the chemical synthesis of various organic compounds. Its reactivity and structural features make it a valuable precursor in the production of specialty chemicals, polymers, or other complex organic molecules.
It is crucial to adhere to safety guidelines when handling Proline, 2-methyl(9CI) to ensure the well-being of individuals and the preservation of the environment.

Upstream product

• 1310563-79-1 1-benzyl-2-methylpyrrolidine-2-carbonitrile 
• 111080-58-1 1-benzyl-2-methylpyrrolidine-2-carboxamide 
• 1415303-35-3 1-(carbamoyl phenylmethyl)-2-cyano-2-methylpyrrolidine 
• 5891-21-4 5-chloro-2-pentanone 
• 848488-83-5 DL-(α-methyl)proline amide 

Downstream Products

• 955029-45-5 (2-methylpyrrolidin-2-yl)methanol 

Relevant articles and documents

Α-substd. provitamin optically active production of phosphorus

PROBLEM TO BE SOLVED: To provide an industrial method practically suitable for producing an optically active α-substituted prolines with short process and mild conditions.SOLUTION: A method of producing an optically active α-substituted prolines (6) includes (d) a step of obtaining an optically active N, α-substituted prolines (5) by hydrolysis of an optically active N, α-substituted proline amides (4), and (e) a step of obtaining an optically active α-substituted prolines (6) by eliminating the optically active N, and a protective group Rof the α-substituted prolines (5).

METHOD FOR PRODUCING OPTICALLY ACTIVE ALPHA-SUBSTITUTED PROLINE

The present invention aims to provide an industrial method practically suitable for producing optically active α-substituted prolines from an acyclic ketone compound by a small number of steps under mild conditions. The present invention relates to a production method of an optically active α-substituted proline (4) and/or an optically active α-substituted prolinamide (5), including (a) reacting an acyclic ketone compound (1) with at least one selected from ammonia, an ammonium salt, primary amine and a salt of primary amine, and a cyanating agent to give a cyclic nitrogen-containing compound (2), (b) hydrating the cyclic nitrogen-containing compound (2) to give an α-substituted prolinamide (3), and (c) resolving the α-substituted prolinamide (3) by one or more of (d) enzymatical hydrolysis, (e) resolution by diastereomeric salt formation, and (f) separation by column chromatography.