162871-02-5Relevant articles and documents
Synthesis of enantiomerically pure 2-alkyl 1-amino cyclopropane-1-carboxylic acid
Calmes, Monique,Daunis, Jacques,Escale, Francoise
, p. 395 - 396 (2007/10/03)
Asymmetric synthesis of 1-amino 2-alkyl cyclopropane carboxylic acids using (1R,2R,5R)-2-hydroxy pinan-3-one as the chiral auxiliary and Corey's ylide as reagent is described.
Asymmetric syntheses of 1-amino-2-phenyl(alkyl)cyclopropanecarboxylic acids by diastereoselective cyclopropanation of highly functionalized monochiral olefines
Alcaraz,Alcaraz, Carmen,Fernandez,Fernaendez, Ma. Dolores,De Frutos,De Frutos, Ma. Pilar,Marco,Marco, Josee L.,Bernabe,Bernabe, Manuel,Foces-Foces,Foces-Foces, Concepcion,Cano,Cano, Felix H.
, p. 12443 - 12456 (2007/10/02)
Monochiral α-benzamidocinnamic esters of N-methylephedrine or mandelic derivatives and benzylidene or alkylidene diketopiperazines, all obtained from oxazolones, react with diazomethane to give moderate to high diastereomeric excesses (d.e.) of pyrazoline
1-Aminocyclopropane-1-carboxylic acid derivatives: A new, general synthesis and NMDA receptor complex binding affinity study
Spadoni,Balsamini,Bedini,Mugnaini
, p. 1663 - 1674 (2007/10/02)
A new synthesis of 1-aminocyclopropane-1-carboxylic acid and of its (E)- and (Z)-2-substituted analogues (R = CH3;i-Pr;C6H5) has been performed by means of the 'diazo-addition' method, starting from N-(diphenylmethylene)-2,3-dehydro-1-amino-1-carboxylate precursors. The (E)- and (Z)-2-phenyl and the (Z)-2-methylcyclopropaneamino acids have been obtained with high diastereospecificity. All the cyclopropaneamino acids prepared were tested for their affinity for some glutamate receptors and resulted inactive, wich the exception of compounds (E)-1b and (Z)-1c which showed a shallow displacement of [H]-glycine binding.
