1629125-65-0Relevant articles and documents
Development of a Scalable Synthesis of BMS-978587 Featuring a Stereospecific Suzuki Coupling of a Cyclopropane Carboxylic Acid
Maity, Prantik,Reddy, V. V. Ramana,Mohan, Jayaraj,Korapati, Satish,Narayana, Harishkumar,Cherupally, Nagesh,Chandrasekaran, Sathishkumar,Ramachandran, Ravikumar,Sfouggatakis, Chris,Eastgate, Martin D.,Simmons, Eric M.,Vaidyanathan, Rajappa
, p. 888 - 897 (2018)
A modified synthetic route to BMS-978587 was developed featuring a chemoselective nitro reduction and a stereospecific Suzuki coupling as the key bond formation steps. A systematic evaluation of the reaction conditions led to the identification of a robust catalyst/ligand/base combination to reproducibly effect the Suzuki reaction on large scale. The modified route avoided several challenges with the original synthesis and furnished the API in high overall yield and purity without recourse to chromatography.
INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
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, (2014/10/04)
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.