- COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES
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The present invention provides compounds, compositions thereof, and methods of using the same.
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Sheet 87/122
(2017/12/27)
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- A New Convenient Synthesis of Alkoxyanthracenes from Alkoxy-9,10- anthraquinones
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Methoxy-9,10-anthraquinones with mono-, di- and tetraether groups at different positions 1a-h can be directly reduced to the corresponding methoxyanthracenes 3a-h in moderate to good yields by zinc in refluxing acetic acid. Under similar conditions, ethyl 1′-anthracenoxyacetate (3i) with the ester group unaffected and 1,8-oxybis(ethyleneoxyethyleneoxy)anthracene (5) were also conveniently synthesized in 65 and 70% yields, respectively.
- Lu, Lingang,Chen, Qiyin,Zhu, Xiaozhang,Chen, Chuanfeng
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p. 2464 - 2466
(2007/10/03)
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- A BIFUNCTIONAL ANTHRAQUINONE SYNTHON
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Commercially available antrarufin has been converted into a bifunctional reagent which will be useful for the preparation of anthraquinone C-glycosides.
- Tius, Marcus A.,Gomez-Galeno, Jorge,Zaidi, Javid H.
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p. 6909 - 6912
(2007/10/02)
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- ESR Spectroscopic Detection of Intramolecular Interactions in Radical Cations of Poly(α-methoxy)triptycenes
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-Cycloaddition of 1,4-benzoquinone to the di- and tetra(α-methoxy)anthracenes 11 yields the diketones 12 which undergo an acid-catalyzed rearrangement to the triptycene hydroquinones 13.Methylation of 13 affords the poly(α-methoxy)triptycenes 4.Aluminium chloride in nitromethane oxidizes the triptycenes 4 to the radical cations 4+* having one 1,4-dialkoxybenzene ring (4b+*, 4c+*, 4e+*) or two (4a+*) or three (4d+*), respectively, of such potential radical centers.The protons of the radical center give rise to hyperfine splittings which are very similar to those found in the ESR spectra of simple cis-1,4-dialkoxybenzene radical cations.The other aromatic protons, but not the bridgehead protons, exhibit a long range hyperfine coupling of 0.011 mT.Selective line broadening in the ESR spectrum of the radical cation 4a+* indicates that intramolecular electron transfer between the 1,4-dimethoxybenzene moieties occurs at a moderate rate.The deceleration of the exchange rate compared to the rate expected for a free radical cation is interpreted in terms of ion pairing.
- Quast, Helmut,Fuchsbauer, Hans-Lothar
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p. 1016 - 1038
(2007/10/02)
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