ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF
Compound derivatives of aconitine are provided, in particular derivatives that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier. The sub
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Page/Page column 30-31
(2012/09/25)
STRUCTURES OF SECOJESACONITINE AND SUBDESCULINE, TWO NEW DITERPENOID ALKALOIDS FROM ACONITUM JAPONICUM THUNB.
The structures of two new diterpenoid alkaloids, secojesaconitine (1) and subdesculine (5), from Aconitum japonicum Thunb. were determined on the basis of spectral and chemical evidence.The structure of an unusual epoxide (1) was condfirmed by X-ray analysis and was the first example of an epoxy ring between C3 and C17.Treatment of the epoxide (1) with acetic acid and acetylation were found to afford the normal C19-aconitine type alkaloid. - KEYWORDS - Aconitum japonicum; diterpenoid alkaloid; secojesaconitine; subdesculine; jesaconitine; X-ray analysis
Bando, Hideo,Wada, Koji,Amiya, Takashi,Fujimoto, Yasuo,Kobayashi, Kimiko
p. 1604 - 1606
(2007/10/02)
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