163105-90-6

Basic information

• Product Name: 2-Methoxypyridine-3-boronic acid
• Synonyms: 2-Methoxypyridine-3-boronic acid ,98%;Methoxypyridinylboronicacid;2-Methoxypyridine-3;2-Methoxypyridine-3-boronic Acid (contains varying aMounts of Anhydride);3-Borono-2-methoxypyridine;Methoxy-3-pyridineboronic;2-Methoxypyridin-3-yl-3-boronic acid;2-METHOXY-3-PYRIDINYL BORONIC ACID
• CAS NO: 163105-90-6
• Molecular Formula: C₆H₈BNO₃
• Molecular Weight: 170.96
• EINECS: -0
• Product Categories: Boronic Acids & Esters;Pyridines;Heterocyclic Compounds;Organoborons;Alkoxy;Boronic Acids & Esters;Boronic Acid;Boronic Acids;Boronic Acids and Derivatives;Heteroaryl;Boronate Ester;Potassium Trifluoroborate;Pyridine;Boron, Nitrile, Thio,& TM-Cpds;Heterocycles
• Mol File: 163105-90-6.mol

Chemical Properties

• Melting Point: 136-138°C
• Boiling Point: 326.4 °C at 760 mmHg
• Flash Point: 151.2 °C
• Appearance: White/Crystalline Powder
• Density: 1.24 g/cm³
• Vapor Pressure: 8.78E-05mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 6.90±0.58(Predicted)
• CAS DataBase Reference: 2-Methoxypyridine-3-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxypyridine-3-boronic acid(163105-90-6)
• EPA Substance Registry System: 2-Methoxypyridine-3-boronic acid(163105-90-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 163105-90-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxypyridine-3-boronic acid is used as a building block or intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile component in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
2-Methoxypyridine-3-boronic acid is also used as a research compound in various chemical studies. Its reactivity and functional groups make it a valuable tool for understanding the properties and behavior of related compounds and for exploring new chemical reactions and synthesis pathways.
Used in Material Science:
In the field of material science, 2-Methoxypyridine-3-boronic acid can be used as a precursor for the development of new materials with specific properties. Its ability to form stable complexes and coordinate with various metal ions makes it a promising candidate for the creation of advanced materials with applications in areas such as catalysis, sensors, and energy storage.

InChI:InChI=1/C6H8BNO3/c1-11-6-5(7(9)10)3-2-4-8-6/h2-4,9-10H,1H3

Upstream product

• 1628-89-3 2-methoxypyridine 
• 112197-15-6 3-iodo-2-methoxypyridine 
• 13472-59-8 3-Bromo-2-methoxypyridine 
• 121-43-7 Trimethyl borate 

Downstream Products

• 835876-06-7 2'-methoxy-[2,3']bipyridinyl-3-ylamine 
• 918898-24-5 1-benzyl-3-indol-1-yl-4-(2-methoxy-pyridin-3-yl)-pyrrole-2,5-dione 
• 918898-25-6 1-benzyl-3-indol-1-yl-4-(2-oxo-1,2-dihydro-pyridin-3-yl)-pyrrole-2,5-dione 
• 918898-26-7 trifluoro-methanesulfonic acid 3-(1-benzyl-4-indol-1-yl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-pyridin-2-yl ester 
• 870563-36-3 N-(4-fluoro-2-(2-methoxypyridin-3-yl)benzyl)-3-(benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxamide 
• 885032-16-6 benzyl 2-methoxy-3',6'-dihydro-3,4'-bipyridine-1'(2'H)-carboxylate 
• 943152-60-1 (R)-{1-[4-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 943152-86-1 (R)-2-{1-[4-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}-isoindole-1,3-dione 
• 943153-38-6 (R)-(1-[3-benzyloxy-4-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl)-carbamic acid tert-butyl ester 
• 881312-54-5 N-{3-cyano-6-fluoro-2-[4-(2-methoxypyridin-3-yl)phenyl]quinolin-4-yl}-D-alanine 
• 936939-51-4 2-hydroxy-5-(2-methoxy-pyridin-3-yl)-benzaldehyde 
• 936939-49-0 2-amino-4-(2-methoxypyridin-3-yl)phenylamine 
• 1029806-13-0 6,7-dimethoxy-1-[4-(2-methoxypyridin-3-yl)benzyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1126422-74-9 5-benzyloxy-3-(2-methoxy-pyridin-3-yl)-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS

The present invention provides a compound of Formula (I): (I) or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by nuclear SET domain-containing protein 2 (NSD2).

Highly efficient one-pot access to functionalized arylboronic acids via noncryogenic bromine/magnesium exchanges

A general and convenient protocol for the electrophilic borylation of aryl Grignard reagents prepared from arylbromides by direct insertion of magnesium in the presence of LiCl or by Mg/Br exchange with iPrMgCl?LiCl has been developed. Various aryl boronic acids were synthesized in a straightforward manner in excellent yields at 0 °C.

Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin

The present invention relates to a method of treating disorders by administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein R1-R8 are as described herein, R4 being aryl or heteroaryl.

Palladium-catalyzed cross-coupling reactions of pyridylboronic acids with heteroaryl halides bearing a primary amine group: Synthesis of highly substituted bipyridines and pyrazinopyridines

(Chemical Equation Presented). A range of halogenated aromatics and heteroaromatics bearing a primary amine group are shown to be suitable substrates for Suzuki cross-coupling reactions with arylboronic acids and pyridylboronic acids under standard conditions, without the need for protection/deprotection steps. New amino-substituted arylpyridines, bipyridines, and pyrazinopyridines have thereby been obtained. Conditions for the efficient syntheses of 2-methoxy-5-pyridylboronic acid 1 and 2-methoxy-3-pyridylboronic acid 2 in ca. 75 g batches have been defined. A 2-fold reaction of 2-amino-5-bromopyrazine with 2,5-dimethoxy-1,4-benzenediboronic acid affords 1,4-dimethoxy-2,5-bis[2-(5-aminopyrazyl)]benzene 31. The X-ray crystal structures of 1 and 31·DMF are reported.

USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS

Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.

New shelf-stable halo- and alkoxy-substituted pyridylboronic acids and their suzuki cross-coupling reactions to yield heteroarylpyridines

New shelf-stable pyridylboronic acids have been synthesized: bromine-lithium exchange followed by reaction with triisopropylborate (TIPB) yielded 2-fluoro-5-pyridylboronic acid (4), 3-bromo-5-pyridylboronic acid (5) and 2-ethoxy-5-pyridylboronic acid (6);