163296-11-5

Basic information

• Product Name: 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, [1α,2α(R*),4α]-
• Synonyms: 1-Piperidinepropanol, α-(1R,2S,4R)-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, (αR)-rel-;1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-, [1α,2α(R*),4α]-(+-)-;1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, [1α,2α(R*),4α]-
• CAS NO: 163296-11-5
• Molecular Formula: C21H29 N O
• Molecular Weight: 311.46
• Mol File: 163296-11-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, [1α,2α(R*),4α]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, [1α,2α(R*),4α]-(163296-11-5)
• EPA Substance Registry System: 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, [1α,2α(R*),4α]-(163296-11-5)

Safety Data

• Hazardous Substances Data: 163296-11-5(Hazardous Substances Data)

Upstream product

• 159651-24-8 C₉H₁₂O 
• 3048-64-4 5-ethenyl-2-norbornene 
• 100-58-3 phenylmagnesium bromide 
• 93778-71-3 C₁₅H₂₃NO 

Relevant articles and documents

Hydrochloric acid method for the new preparation method (by machine translation)

The present invention provides a kind of hydrochloric acid I for the new preparation method, which belongs to the technical field of pharmaceutical and chemical synthesis, it solves the problem of large-scale preparation-oriented method for the hydrochloric acid, the product made in accordance with the latest European Pharmacopoeia standards. The method in order to 5 - vinyl - 2 - norbornene the alkene is starting material selectively oxidize to make the appearance of the key 5 - acetyl norbornene, then the Mannich reaction, from the outside to the isomerization salt forming reaction, Grignard reaction and salt forming reaction to obtain the product. The invention raw materials are easy, low cost, simple operation, mild reaction conditions, has good industrial application value. (by machine translation)

Patch and production method thereof

The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of the drug can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.

Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins

A compound and method are disclosed for reducing neurotoxic effects (such as seizures and brain damage) caused by cholinergic agents such as soman (a nerve gas) and pilocarpine (a convulsant drug used to study the mechanisms of epilepsy). Effective treatment can be provided by administering an aryl-cycloalkylalkanolamine substance having the general formula: STR1 The compoudns procyclidine, biperiden, and trihexyphenidyl fall within this class of compounds. Although not previously recognized to be effective against soman or other cholinergic neurotoxins, all three representative compounds have been discovered to be highly effective against all cholinergic neurotoxins tested to data, even when administered after actual seizures begin.

Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury

Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an aryl-cycloalkyl-alkanolamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.