- PROCESS FOR THE PREPARATION OF CYCLOPROPANE COMPOUNDS USING DIAZO-COM POUNDS
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A process for the continuous production of a reaction product of a diazo‐compound and a substrate in a multi‐stage flow reactor is disclosed.
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Page/Page column 10
(2020/01/24)
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- PROCESS FOR THE CYCLOPROPANATION OF OLEFINS USING N-METHYL-N-NITROSO COMPOUNDS
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A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.
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Page/Page column 11-12
(2017/04/11)
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- METHOD FOR THE PREPARATION OF DIAZOALKANES
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The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used.
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Paragraph 0064-0071
(2015/02/19)
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- A METHOD FOR THE PREPARATION OF DIAZOALKANES
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The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used,
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Page/Page column 14; 15
(2013/08/15)
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