- METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER
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The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
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Paragraph 0292; 0304
(2015/09/23)
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- Heterocycle-to-heterocycle route to quinoline-4-amines: Reductive heterocyclization of 3-(2-nitrophenyl)isoxazoles
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A variety of quinoline-4-amines were synthesized from substituted 3-(2-nitrophenyl)isoxazoles utilizing Zn0 or Fe0 dust and HOAc using a reductive heterocyclization process. The starting isoxazoles were synthesized from readily available starting materials. A brief survey of functional groups tolerated in this reductive heterocyclization was performed and several 10-amino-3,4-dihydrobenzo[b][1,6]naphthyridin-1(2H)-one and 9-amino-3,4-dihydroacridin-1(2H)-one examples were synthesized.
- Coffman, Keith C.,Duong, Vy,Bagdasarian, Alex L.,Fettinger, James C.,Haddadin, Makhluf J.,Kurth, Mark J.
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p. 7651 - 7657
(2015/04/22)
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- Chitosan-SO3H: An efficient, biodegradable, and recyclable solid acid for the synthesis of quinoline derivatives via Friedl?nder annulation
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Chitosan-SO3H is found to catalyze the Friedl?nder condensation/annulation reaction of 2-aminoaryl ketones with α-methyleneketones to produce the corresponding quinoline derivatives in high yields in short reaction times. The use of recyclable
- Reddy, B.V. Subba,Venkateswarlu,Reddy, G. Niranjan,Reddy, Y.V. Rami
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p. 5767 - 5770
(2013/10/01)
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- Synthesis and in vitro antiproliferative evaluation of pyrimido[5,4-c] quinoline-4-(3H)-one derivatives
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A series of pyrimido[5,4-c]quinoline-4-(3H)-one derivatives variously substituted at positions 2 and 3 were synthesized and evaluated for their in vitro antiproliferative activities against a panel of six human cancer cell lines. Biological evaluation rev
- Ai, Yong,Liang, Yong-Ju,Liu, Jian-Chao,He, Hong-Wu,Chen, Yu,Tang, Chu,Yang, Guang-Zhong,Fu, Li-Wu
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experimental part
p. 206 - 213
(2012/02/15)
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- METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER
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The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
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- SWEET FLAVOR MODIFIER
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The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
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- Synthesis and structure elucidation of five new pyrimido[5,4-c]quinoline- 4(3H)-one derivatives using 1D and 2D NMR spectroscopy
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Five new 2-(amino/aroxy)-5-methylpyrimido[5,4-c]quinolin-4(3H)-one derivatives have been designed and synthesized via an aza-Wittig reaction, and the structure elucidation was accomplished using extensive 1D (1H, 13C) and 2D NMR spec
- Ai, Yong,Yang, Guangzhong,Liu, Jianchao,Chen, Yu,Liu, Lu,Lei, Xinxiang
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experimental part
p. 955 - 959
(2011/07/30)
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- A structure-based design approach to the development of novel, reversible AChE inhibitors
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Chimeras of tacrine and m-(N,N,N-Trimethylammonio)trifluoroacetophenone (1) were designed as novel, reversible inhibitors of acetylcholinesterase. On the basis of the X-ray structure of the apoenzyme, a molecular modeling study determined the favored attachment positions on the 4-aminoquinoline ring (position 3 and the 4-amino nitrogen) and the favored lengths of a polymethylene link between the two moieties (respectively 5-6 and 4-5 sp3 atoms). Seven compounds matching these criteria were synthesized, and their inhibitory potencies were determined to be in the low nanomolar range. Activity data for close analogues lacking some of the postulated key features showed that our predictions were correct. In addition, a subsequent crystal structure of acetylcholinesterase complexed with the most active compound 27 was in good agreement with our model. The design strategy is therefore validated and can now be developed further.
- Doucet-Personeni,Bentley,Fletcher,Kinkaid,Kryger,Pirard,Taylor,Taylor,Taylor,Viner,Silman,Sussman,Greenblatt,Lewis
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p. 3203 - 3215
(2007/10/03)
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- Synthesis of 4-Quinolone Derivatives
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Routes to 4-amino-2-alkyl substituted quinoline-3-carboxylic acids and 3-acyl-2-phenyl and 3-acyl-2-alkyl substituted 4-quinolones have been devised by application of isoxazole chemistry and Heck-Stille couplings.
- Jensen, Soeren,Torssell, Kurt B. G.
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