- METHOD FOR THE SYNTHESIS OF HETEROCYCLIC HYDROGEN PHOSPHINE OXIDE
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The present invention is related to a method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula (I), wherein: - R is a aliphatic or aromatic divalent group optionally comprising one or more heteroatoms and optionally comprising one or more substituents and - X and Y are independently selected from -O-, -C(O)O- and -NR'- wherein R' is a monovalent group optionally comprising one or more heteroatoms comprising the steps of: a) forming a reaction mixture by mixing a compound having the general formula HX-R-YH and tetraphosphorus hexaoxide; b) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.
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Paragraph 0064
(2016/03/13)
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- Novel routes to aminophosphonic acids: Interaction of dimethyl H-phosphonate with hydroxyalkyl carbamates
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It was found that the reaction of dimethyl H-phosphonate (1) with 2-hydroxyalkyl-N-2′-hydroxyalkyl carbamates at 135°C includes several chemical reaction steps: (i) chemical transforma-tions of 1-methyl-2- hydroxyethyl-N-2′-hydroxyethyl carbamate (2) and 2-methyl-2-hydroxyethyl- N-2′-hydroxyethyl carbamate (3); (ii) transesterification of dimethyl H-phosphonate with 2 and 3, and with secondary hydroxyl-containing compounds that are formed during the course of the chemical transformation of 2-hydroxyalkyl-N-2′-hydroxyalkyl carbamates; (iii) hydrolysis of 1 and dialkyl H-phosphonates, formed via transesterification of 1 with secondary hydroxyl-containing compounds. The interaction was studied by means of 1H, 13C, 31P NMR, and FAB mass spectroscopy.
- Troev,Koseva,Haegele
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p. 119 - 124
(2008/09/18)
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- New method of alkylene phosphonate preparation
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A new method of alkylene phosphonate preparation has been elaborated, based on the reaction of the corresponding cyclic ethers and phosphonic acid in the presence of acetic anhydride.
- Klosinski
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p. 2025 - 2028
(2007/10/02)
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