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N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE is a DNA adduct of glycidamide, which is an off-white solid. It is formed through the reaction of glycidamide with guanine, a base in DNA. This adduct can potentially lead to DNA damage and mutations, which may contribute to the development of cancer.

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  • 163734-06-3 Structure
  • Basic information

    1. Product Name: N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE
    2. Synonyms: 2-Amino-1,6-dihydro-a-hydroxy-6-oxo-7H-purine-7-propanamide;N7-GA-Gua;2-Amino-1,6-dihydro- -hydroxy-6-oxo-7H-purine-7-propanamide);N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE
    3. CAS NO:163734-06-3
    4. Molecular Formula: C8H10N6O3
    5. Molecular Weight: 238.2034
    6. EINECS: N/A
    7. Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Nucleotides, Bases & Related Reagents
    8. Mol File: 163734-06-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 2.07g/cm3
    6. Refractive Index: 1.91
    7. Storage Temp.: -20°C Freezer
    8. Solubility: DMSO (Very Slightly, Heated)
    9. CAS DataBase Reference: N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE(163734-06-3)
    11. EPA Substance Registry System: N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE(163734-06-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 163734-06-3(Hazardous Substances Data)

163734-06-3 Usage

Uses

Used in Research Applications:
N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE is used as a research tool for studying the mechanisms of DNA damage and repair, as well as the role of glycidamide in the formation of DNA adducts. It helps researchers understand the potential carcinogenic effects of glycidamide and its impact on DNA stability and function.
Used in Pharmaceutical Industry:
N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE is used in the development of drugs and therapies targeting DNA repair mechanisms and cancer treatment. By studying the interaction between this DNA adduct and various compounds, researchers can identify potential therapeutic agents that can prevent or reverse the damaging effects of glycidamide on DNA.
Used in Toxicology Studies:
N7-(2-CARBAMOYL-2-HYDROXYETHYL)GUANINE is used in toxicology studies to evaluate the potential genotoxicity of glycidamide and related compounds. This helps in assessing the safety and risk associated with exposure to these chemicals, as well as in the development of strategies to mitigate their harmful effects on human health.

Check Digit Verification of cas no

The CAS Registry Mumber 163734-06-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,7,3 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 163734-06:
(8*1)+(7*6)+(6*3)+(5*7)+(4*3)+(3*4)+(2*0)+(1*6)=133
133 % 10 = 3
So 163734-06-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N6O3/c9-5(16)3(15)1-14-2-11-6-4(14)7(17)13-8(10)12-6/h2-3,15H,1H2,(H2,9,16)(H3,10,12,13,17)

163734-06-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N7-(2-Carbamoyl-2-hydroxyethyl)guanine

1.2 Other means of identification

Product number -
Other names 3-(2-amino-6-oxo-3H-purin-7-yl)-2-hydroxypropanamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:163734-06-3 SDS

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