- Synthesis method of L-prolinamide
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The invention belongs to the field of organic synthesis, and discloses a synthesis method of L-prolinamide. The method comprises steps of S1, dissolving an initial material, L-proline, in water and then reacting with acetic anhydride, after reaction, extracting and drying to prepare N-acetyl-L-proline; S2, in a solvent system, performing a reaction on a raw material, N-acetyl-L-proline prepared inS1 and thionyl chloride, then concentrating and drying to obtain a compound; S3, dripping aqueous ammonia in the compound prepared in S2 as a raw material so as to react, filtering and preparing 1-acetyl-2-pyrrolidinecarboxamide; and S4, dripping HC1 into the 1-acetyl-2-pyrrolidinecarboxamide prepared in S3 as a raw material, so as to react, then concentrating, filtering and drying to prepare L-prolinamide. In the reaction process of the synthesis method provided by the invention, common reagent raw materials are used, the costs are low, the reaction conditions are mild, the chiral purity ishigh, the yield is high, the environment pressure is low, and the synthesis method is suitable for large-scale production.
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Paragraph 0030; 0033; 0035; 0038; 0040; 0043; 0045; 0048
(2019/01/16)
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- Organocatalyzed Baylis-Hillman reaction: An enantioselective approach
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A convenient protocol has been developed for the synthesis of Baylis-Hillman adducts in the presence of a base and an organocatalyst. We have designed and synthesized organocatalysts based on hydrogen bonding using a pyrrolidine ring as the backbone and applied them to Baylis-Hillman transformations. This method provides products in good to high yields (73-90%) and with excellent enantiomeric excesses (up to 96%) and reasonable reaction times.
- Thorat, Prashant B.,Goswami, Santosh V.,Khade, Bhimrao C.,Bhusare, Sudhakar R.
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p. 1320 - 1325
(2012/11/06)
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- Sodium 2-ethylhexanoate: A mild acid scavenger useful in acylation of amines
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A highly useful method for the acylation of amines with acid chlorides utilizing sodium 2-ethylhexanoate as the base is described. This procedure is superior to the Schotten-Baumann conditions whenever the product is water soluble.
- Fitt, John,Prasad, Kapa,Repic, Oljan,Blacklock, Thomas J.
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p. 6991 - 6992
(2007/10/03)
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- Vinyl carboxylate an acylating reagent for selective acylation of amines and diols
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Vinyl group of vinyl alkylate (C=2 or 16) and vinyl benzoate have been found to be a good leaving group in acylation of alcohols (40-50% yield) and amines (in 60-90% yield).
- Chen,Chen,Chen,Wang
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p. 3583 - 3584
(2007/10/02)
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- Conformational Investigations of α,β-Dehydropeptides. I. Synthesis of Model Dipeptides
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Three series of model dipeptides: Ac-Pro-X-NHMe, where X = L-, D- and Δ-Ala, L-, D- and (Z)-Δ-Phe and L-, D- and Δ-Val, designed for conformational investigation of α,β-dehydroamino acid effect on peptide chain β-turn have been synthesized.
- Pietrzynski, Grzegorz,Kubica, Zbigniew,Rzeszotarska, Barbara
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p. 363 - 370
(2007/10/02)
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