164025-54-1Relevant articles and documents
Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni's Reagent
Chen, Yanchi,Ma, Guobin,Gong, Hegui
supporting information, p. 4677 - 4680 (2018/08/07)
This work illustrates a reductive cross-electrophile coupling protocol for trifluoromethylation of alkyl iodides under Cu-catalyzed/Ni-promoted reaction conditions. The use of diboron esters as the terminal reductant allows the effective generation of the alkyl-CF3 products with excellent functional group tolerance and broad substrate scope. A mechanism involving a reaction of alkyl-Cu with Togni's reagent was proposed.
Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides
Rezazadeh, Sina,Devannah, Vijayarajan,Watson, Donald A.
supporting information, p. 8110 - 8113 (2017/06/28)
Enabled by nickel catalysis, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described. Compatible with primary, secondary, and tertiary alkyl iodides; and tolerant of a wide range of functional groups, this method allows rapid access to diverse nitroalkanes.
A remarkably useful sulfur bridge as synthetic lever in an approach to Javanicin B
Dion, Amélie,Spino, Claude
, p. 894 - 919 (2017/07/27)
A concise and efficient synthesis of a non-racemic advanced intermediate to the quassinoid javanicin B is disclosed. The strategy is centred on a triple diene-transmissive Diels-Alder cycloaddition to form the four rings of javanicin B. A sulfur bridge plays several crucial roles allowing an intramolecular cycloaddition to occur with complete stereoselectivity, controlling the stereochemical outcome of another cycloaddition, and transforming into a pivotal electrophile for the introduction of a particularly hindered methyl group.
EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 85, (2012/10/18)
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the
Rotaxanes of cyclic peptides
Aucagne, Vincent,Leigh, David A.,Lock, Julia S.,Thomson, Andrew R.
, p. 1784 - 1785 (2007/10/03)
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal
Attempts directed towards the synthesis and determination of the absolute stereochemistry of iso-cladospolide-B and cladospolides-B and C
Sharma,Reddy, J. Janardhan,Reddy, K. Laxmi
, p. 6531 - 6535 (2007/10/03)
Attempts to synthesise iso-cladospolide-B, cladospolide-B and cladospolide-C resulted in macrolides 1, 2 and 4 along with butenolide 3. Of the three stereogenic centres, the C-4/C-5 vic-diol was obtained from tartaric acid and d-glucose, while the C-11 st
The furan approach to oxacycles: Synthesis of medium-size 2,3-disubstituted oxacycles
Pérez, Manuel,Canoa, Pilar,Gómez, Generosa,Terán, Carmen,Fall, Yagamare
, p. 5207 - 5209 (2007/10/03)
We describe an efficient new approach for the synthesis of medium-size oxacycles that is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular Michael addition. This present study enlarges the scope of the furan approach strategy for the synthesis of oxepanes.
Synthesis of the tetracyclic ABCE ring subunit I, bearing the 13- membered azacycle, of manzamine A
Li, Shouming,Yamamura, Shosuke
, p. 8691 - 8710 (2007/10/03)
The tetracyclic ABCE ring, which bears the crucial 13-membered azacycle, of manzamine A has been synthesized through the corresponding bicyclic BC ring subunit as a promising synthetic intermediate.
Synthetic studies on manzamine A: Construction of the tetracyclic ABCE ring substructure I
Li, Shouming,Yamamura, Shosuke,Hosomi, Hiroki,Ohba, Shigeru
, p. 2601 - 2604 (2007/10/03)
The synthesis of the tetracyclic ABCE ring, which bears the crucial 13- membered azacycle, of manzamine A is described.
A short synthesis of 4-substituted 1-(hydroxyalkyl)-1H-pyrazolo[3,4-d]pyrimidines
Zacharie, Boulos,Connolly, Timothy P.,Rej, Rabindra,Attardo, Giorgio,Penney, Christopher L.
, p. 2271 - 2278 (2007/10/03)
A simple and practical procedure was developed for the preparation of 4-substituted-1-(hydroxyalkyl)-1H-pyrazolo[3,4-d]pyrimidines. This was achieved by reacting nucleobase 3a or 3b with cesium carbonate or DBU in the presence of various alkyl iodides at 0°C in DMF. This procedure appears to be of general utility, proceeds in reasonable yield, and is applicable to different alkyl chain lengths including protected and unprotected alcohols. The synthetic utility of this approach is demonstrated by the facile synthesis of ST 689, a potent immunostimulatory drug.