164073-80-7Relevant articles and documents
Functional Porphyrinic Metal–Organic Framework as a New Class of Heterogeneous Halogen-Bond-Donor Catalyst
Chen, Yu-Sheng,Cheng, Qigan,Ma, Shengqian,Nafady, Ayman,Shan, Chuan,Wojtas, Lukasz,Zhang, Weijie,Zhang, X. Peter
, p. 24312 - 24317 (2021/10/04)
Biomimetic metal-organic frameworks have attracted great attention as they can be used as bio-inspired models, allowing us to gain important insights into how large biological molecules function as catalysts. In this work, we report the synthesis and utilization of such a metal-metalloporphyrin framework (MMPF) that is constructed from a custom-designed ligand as an efficient halogen bond donor catalyst for Diels–Alder reactions under ambient conditions. The implementation of fabricated halogen bonding capsule as binding pocket with high-density C?Br bonds enabled the use of halogen bonding to facilitate organic transformations in their three-dimensional cavities. Through combined experimental and computational studies, we showed that the substrate molecules diffuse through the pores of the MMPF, establishing a host-guest system via the C?Br???π interaction. The formation of halogen bonds is a plausible explanation for the observed boosted catalytic efficiency in Diels–Alder reactions. Moreover, the unique capability of MMPF highlights new opportunities in using artificial non-covalent binding pockets as highly tunable and selective catalytic materials.
COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION
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Page/Page column 60; 61, (2021/06/11)
The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.
Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid
Pradhan, Tuhin,Maiti, Sukhendu,Kumar, Rajesh,Lee, Yun Hak,Kim, Jong Wan,Lee, Joung Hae,Kim, Jong Seung
, p. 1 - 6 (2015/06/02)
Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ~60 μM, higher: ~700 μM and normal: ~120-380 μM) with 'turn-on' fluorogenic behaviour.
Crystal engineering of a microporous, catalytically active fcu topology MOF using a custom-designed metalloporphyrin linker
Meng, Le,Cheng, Qigan,Kim, Chungsik,Gao, Wen-Yang,Wojtas, Lukasz,Zaworotko, Michael J.,Zhang, X. Peter,Ma, Shengqian,Chen, Yu-Sheng
supporting information, p. 10082 - 10085,4 (2020/09/09)
A 12-connected fcu metal-organic framework (MOF), MMPF-3, has been prepared using a CoII metalloporphyrin. MMPF-3 is comprised of the same polyhedral supermolecular building blocks as the prototypal fcu-MOF, fcu-MOF-1, and its nanoscale cavities feature 18 catalytically active cobalt centers. The high density (ca. 5 cobalt sites/nm3) affords MMPF-3 superior performance in catalytic epoxidation of trans-stilbene compared to other MOFs. Copyright
SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF
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Page/Page column 62, (2009/01/23)
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no- reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods.