Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases
Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-α in cells. The Royal Society of Chemistry 2008.
Lienard, Benoit M.,Conejo-Garcia, Ana,Stolze, Ineke,Loenarz, Christoph,Oldham, Neil J.,Ratcliffe, Peter J.,Schofield, Christopher J.
supporting information; experimental part
p. 6393 - 6395
(2009/04/13)
Selective inhibition of Fe- versus Cu/Zn-superoxide dismutases by 2,3-dihydroxybenzoic acid derivatives
A series of catechol derivatives were synthesised and tested for their ability to inactivate the iron-containing superoxide dismutase (Fe-SOD) from Escherichia coli and the bovine erythrocytes Cu/Zn-SOD. Incubation of catechols with Fe- or Cu/Zn SODs resu