1643-39-6Relevant articles and documents
Molecular structures, DFT studies and their photophysical properties in solution and solid state. Microwave-assisted multicomponent synthesis of organotin bearing Schiff bases
Cantón-Díaz, Arelly M.,Mu?oz-Flores, Blanca M.,Moggio, Ivana,Arias, Eduardo,Turlakov, Gleb,Del Angel-Mosqueda, Casiano,Ramirez-Montes, Pedro I.,Jiménez-Pérez, Víctor M.
, p. 642 - 650 (2019)
A couple of luminescent organotin compounds derivated from ligands-ONO were obtained by multicomponent microwave assisted synthesis in short time (15 min) and good yields: ((E)-8, 8-8-diphenylbenzo[d] naphtho [1,2-h][1,3,6,2] dioxazastannonine (1) and (E)
Reactions of isomeric 3,6- and 3,5-di-tert-butyl-ortho-benzoquinones
Vol'eva, V. B.,Prokof'eva, T. I.,Prokof'ev, A. I.,Belostotskaya, I. S.,Komissarova, N. L.,Ershov, V. V.
, p. 1720 - 1724 (1995)
The interaction of 3,6-di-tert-butyl-ortho-benzoquinone (1) and 3,5-di-tert-butyl-ortho-benzoquinone (2) with NH3 in water-alcohol medium and with (NH4)2 CO3 in a solid phase has been studied.Redox processes with participation of a nucleophile of the medi
Fluorescent Molecular Rotors of Organoboron Compounds from Schiff Bases: Synthesis, Viscosity, Reversible Thermochromism, Cytotoxicity, and Bioimaging Cells
Ibarra-Rodr??guez, Marisol,Mu?oz-Flores, Blanca M.,Dias, H. V. Rasika,Sánchez, Mario,Gomez-Trevi?o, Alberto,Santillan, Rosa,Farfán, Norberto,Jiménez-Pérez, Víctor M.
, p. 2375 - 2385 (2017)
We report the design, synthesis, and characterization of two new fluorescent molecular rotors of boron derived from Schiff bases: (2,4,8,10-tetra-tert-butyl-6-phenyldibenzo[d,h][1,3,6,2]dioxazaboronine (3) and 1,4-bis(2,4,8,10-tetra-tert-butyldibenzo[d,h][1,3,6,2]dioxazaboronin-6-yl)benzene (4), as well as the free ligand 2-[[(3,5-di-tert-butyl-2-hydroxyphenyl)imino]methyl]-4,6-di-tert-butylphenol 1. All compounds were fully characterized by NMR (1H,11B, and13C), IR, UV/vis, fluorescence spectroscopy, and high-resolution mass spectrometry. The crystal structures of 3 and 4 showed tetracoordinated boron atoms with semiplanar skeleton ligands. The free rotation of the fluorescent molecular rotor, only observed in the binuclear compound, was decreased with increasing viscosity, while the quantum yield was increased. Interestingly, the property of reversible thermochromism was found in organoboron 4 in the solid state. DFT calculations to determine the both complexes have free rotation around the CPh-B1 bond. The boron compounds 3 and 4 have shown low cytotoxicity activity in cell line A-431 and low green staining in cells.
Tridentate [ONO] tungsten coordination compound and optical application thereof
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, (2021/05/29)
The invention provides a tridentate [ONO] tungsten coordination compound and optical application thereof, and the tridentate [ONO] tungsten coordination compound is divided into but not limited to three structures, namely a structure I, a structure II and
Metal-Free Oxidative Condensation of Catechols, Aldehydes and NH4OAc towards Benzoxazoles
Dong, Jianyu,Geng, Furong,Su, Lebin,Wu, Shaofeng,Yin, Shuang-Feng,Zhou, Dan,Zhou, Yongbo
supporting information, p. 3607 - 3614 (2021/07/28)
Benzoxazoles extensively exist in biologically active compounds, natural products, pharmaceuticals and functional materials. Thus, facile and green synthesis of such valuable compounds from easily available substrates will make a contribution to drug, material, and fine chemistry. A method for the synthesis of benzoxazoles from catechols, aldehydes and ammonium acetate is developed using NaIO4 as oxidant under metal- and additive-free conditions. A broad range of benzoxazoles including some fluorescent whitening agents, JTP-426467 and tafamidis analogues are synthesized in 56–95% yields with outstanding functional group tolerance. Mechanistic investigations suggest that an interesting o-iminocyclohexa-diene alcohol intermediate is involved in the reaction. These salient features of the protocol make it an alternative for the synthesis of benzoxazoles. (Figure presented.).
Controllable synthesis of 2- And 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols
Dong, Kui,Jin, Xiao-Ling,Chen, Shihao,Wu, Li-Zhu,Liu, Qiang
, p. 7941 - 7944 (2020/08/14)
We present herein a method for the controllable synthesis of 3-aryl-benzomorpholine and 2-aryl-benzomorpholine cycloadducts via cross-coupling/annulation between electron-rich 2-aminophenols and 4-vinylphenols. Molecular oxygen was successfully used in the reaction as the terminal oxidant and the complete inversion of chemoselectivity was achieved by the adjustment of the solvents and bases at room temperature.
A new bis-phenolate mesoionic carbene ligand for early transition metal chemistry
Baltrun, Marc,Watt, Fabian A.,Schoch, Roland,W?lper, Christoph,Neuba, Adam G.,Hohloch, Stephan
, p. 14611 - 14625 (2019/10/16)
We report the synthesis of a new pincer-type triazolylidene ligand precursor H3L[Cl] with redox-active 3,5-di-tert-butylphenolate substituents on a multigram scale following a converging ten-step route. The potential of this new mesoionic carbe
Synthesis of Mono- and Dinuclear Vanadium Complexes and Their Reactivity toward Dehydroperoxidation of Alkyl Hydroperoxides
Schmidt, Anna-Corina,Hermsen, Marko,Rominger, Frank,Dehn, Richard,Teles, Joaquim Henrique,Sch?fer, Ansgar,Trapp, Oliver,Schaub, Thomas
, p. 1319 - 1332 (2017/02/15)
Several vanadium(V) complexes with either dipic-based or Schiff base ligands were synthesized. The complexes were fully characterized by elemental analysis, IR, 1H, 13C, and 51V NMR spectroscopy, as well as mass spectrometry and X-ray diffraction. Furthermore, they were tested toward their catalytic deperoxidation behavior and a significant difference between 4-heptyl hydroperoxide and cyclohexyl hydroperoxide was observed. In the case of 4-heptyl hydroperoxide, the selectivity toward the corresponding ketone was higher than with cyclohexyl hydroperoxide. DFT calculations performed on the vanadium complex showed that selective decomposition of secondary hydroperoxides with vanadium(V) to yield the corresponding ketone and water is indeed energetically feasible. The computed catalytic path, involving cleavage of the O-O bond, hydrogen transfer, release of ketone/water, and finally addition of hydroperoxide, can proceed without the generation of radical species.
Improvement in Aluminum Complexes Bearing Schiff Bases in Ring-Opening Polymerization of ?-Caprolactone: A Five-Membered-Ring System
Lee, Chieh-Ling,Lin, Ya-Fan,Jiang, Man-Ting,Lu, Wei-Yi,Vandavasi, Jaya Kishore,Wang, Li-Fang,Lai, Yi-Chun,Chiang, Michael Y.,Chen, Hsuan-Ying
, p. 1936 - 1945 (2017/06/13)
A series of five- and six-membered-ring Al complexes bearing Schiff bases was synthesized and their application to the ring-opening polymerization of ?-caprolactone (CL) was studied. The five-membered-ring Al complexes have been shown to have a significan
Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
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, (2015/09/22)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.