16434-32-5Relevant articles and documents
Synthesis, characterization, and antibacterial activity of the schiff bases derived from thiosemicarbazide, salicylaldehyde, 5-bromosalicylaldehyde and their copper(II) and nickel(II) complexes
Joseph, Jisha,Mary,Sidambaram, Raja
, p. 930 - 933 (2010)
Two Schiff bases salicylidene thiosemicarbazone (SALTSC) and 5-bromosalicylidene thiosemicarbazone (5-BrSALTSC) were prepared in excellent yield via the condensation of salicylaldehyde/5-bromosalicylaldehyde and thiosemicarbazide. The copper (II) and nick
Synthesis, characterization, and evaluation of silver(I) complexes with mixed-ligands of thiosemicarbazones and diphenyl(p-tolyl)phosphine as biological agents
Abdul Halim, Syahrina Nur 'Ain,Nordin, Fariza Juliana,Mohd Abd Razak, Mohd Ridzuan,Mohd Sofyan, Nur Rahimah Fitrah,Abdul Halim, Siti Nadiah,Rajab, Nor Fadilah,Sarip, Rozie
, p. 879 - 893 (2019)
Five new silver(I) complexes were synthesized with mixed ligands of thiosemicarbazone derivatives and diphenyl(p-tolyl)phosphine in search of new biologically active compounds. A CHN elemental analysis, powder X-ray diffraction (PXRD) data and several spectroscopic techniques such as Fourier-transform infrared spectroscopy, energy-dispersive X-ray, 1H, 13C, and 31P{1H} NMR were performed to elucidate the structure of these complexes. Elemental analysis suggested that the stoichiometry of the complexes formed by the reaction of silver nitrate with thiosemicarbazone in the presence of (p-tolyl)PPh2 was indeed 1:2:1 molar ratio. The silver ions were discovered to be coordinated to the sulfur of thiosemicarbazone and phosphorus of (p-tolyl)PPh2, having a tetrahedral geometry based on the spectroscopic data obtained. The PXRD patterns were studied to see the degree of crystallinity of the complexes. The in vitro antiproliferative activity of these complexes was investigated toward the MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell line, which yielded IC50 values in low micromolar range. The antiplasmodial activity of these complexes was also examined against chloroquine-resistant Plasmodium falciparum parasite which demonstrated good activity and further tested for their selectivity index.
Ligand Control on the Synthesis and Redox Potency of Mononuclear Manganese-(III) and -(IV) Complexes with Tridentate ONS Co-ordination
Mukhopadhyay, Rina,Bhattacharjee, Samiran,Bhattacharyya, Ramgopal
, p. 2799 - 2804 (1994)
Trifunctional (ONS) Schiff bases H2L1 and H2L2 (H2L1 = 5-R-salicylaldehyde thiosemicarbazone; H2L2 = 5-R-salicylaldehyde 4-phenylthiosemicarbazone; R = H, Me or Br) furnished manganese (IV) complexes of the type
Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines
Aziz, Hamid,Mahmood, Abid,Zaib, Sumera,Saeed, Aamer,El-Seedi, Hesham R.,Pelletier, Julie,Sévigny, Jean,Iqbal, Jamshed
, p. 6140 - 6153 (2020/08/14)
Alkaline phosphatases are homodimeric protein enzymes which removes phosphates from several types of molecules. These catalyze the hydrolysis of monoesters in phosphoric acid which in turn catalyze a transphosphorylation reaction. Thiazoles are a privileged class of heterocyclic compounds which may potentially serve as effective phosphatase inhibitors. In this regard, the present research paper reports the facile synthesis and characterization of substituted 1-benzylidene-2-(4-tert-butylthiazol-2-yl) hydrazines with excellent yields. The synthesized compounds were tested for inhibitory potential against alkaline phosphatases. The compound 1-(4-Hydroxy, 3-methoxybenzylidene)-2-(4-tert-butylthiazol-2-yl) hydrazine (5e) was found to be the most potent inhibitor of human tissue non-alkaline phosphatase in this group of molecules with an IC50 value of 1.09 ± 0.18 μM. The compound 1-(3,4-dimethoxybenzylidene)-2-(4-tert-butylthiazol-2-yl) hydrazine (5d) exhibited selectivity and potency for human intestinal alkaline phosphatase with an IC50 value of 0.71 ± 0.02 μM. In addition, structure activity relationship and molecular docking studies were performed to evaluate their binding modes with the target site of alkaline phosphatase. The docking analysis revealed that the most active inhibitors showed the important interactions within the binding pockets of human intestinal alkaline phosphatase and human tissue non-alkaline phosphatase and may be responsible for the inhibitory activity of the compound towards the enzymes. Therefore, the screened thiazole derivatives provided an outstanding platform for further development of alkaline phosphatase inhibitors.
A facile synthesis of some novel thiazoles, arylazothiazoles, and pyrazole linked to thiazolyl coumarin as antibacterial agents
Abdel-Aziem, Anhar,Baaiu, Basma Saad,Elbazzar, Awad Wanis,Elabbar, Fakhri
, p. 2522 - 2530 (2020/07/10)
5-bromosalicylaldehyde (1) was reacted with thiosemicarbazide to afford thiosemicarbazone derivative 2. The latter underwent cyclocondensation upon reaction with α-haloester, α-haloketone as well as hydrazonoyl halides affording 1,3-thiazoles and arylazot
Fluorescent probe adopting Schiff base type structure as well as preparation method and applications of fluorescent probe
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Paragraph 0042-0044, (2018/12/13)
The invention relates to a fluorescent probe adopting a Schiff base type structure. The structural formula of the fluorescent probe is shown in the description; and R is any one of H, Br and Cl. Thiosemicarbazide is dissolved in absolute ethyl alcohol, a
Synthesis of some nitrogen heterocycles and in vitro evaluation of their antimicrobial and antitumor activity
Hasanen,El-Deen,El-Desoky,Abdalla
, p. 537 - 553 (2014/02/14)
Treatment of ethyl β-aryl-α-cyanoacrylate (2a, b) with thiourea, guanidine hydrochloride, and thiosemicarbazide in presence of anhydrous potassium carbonate in methanol led to formation of pyrimidine derivatives 3 and 5 and thiosemicarbazone derivative 9.
Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: Antibacterial, antifungal and in vitro antileukemia activity
Pahontu, Elena,Fala, Valeriu,Gulea, Aurelian,Poirier, Donald,Tapcov, Victor,Rosu, Tudor
, p. 8812 - 8836 (2013/09/23)
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H2L1-H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared
Thiosemicarbazone copper complexes as competent catalysts for olefin cyclopropanations
Youssef, Nabil S.,El-Seidy, Ahmed M.A.,Schiavoni, Marco,Castano, Brunilde,Ragaini, Fabio,Gallo, Emma,Caselli, Alessandro
experimental part, p. 94 - 103 (2012/09/25)
New copper complexes of several thiosemicarbazones have been prepared and characterized. All complexes have been prepared by employing Cu (II) acetate hydrate, but analytical and spectroscopical data for the isolated complexes revealed that in most cases
Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
Arshad, Afsheen,Osman, Hasnah,Bagley, Mark C.,Lam, Chan Kit,Mohamad, Suriyati,Zahariluddin, Anis Safirah Mohd
experimental part, p. 3788 - 3794 (2011/11/06)
Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a-d and 15a-h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.
