164394-23-4

Basic information

• Product Name: 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID
• Synonyms: 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID;5-Nitro-1,10-phenanthroline-2,9-dicarboxylic acid hydrate, 98%
• CAS NO: 164394-23-4
• Molecular Formula: C14H7N3O6
• Molecular Weight: 313.22
• Mol File: 164394-23-4.mol

Chemical Properties

• Melting Point: ca 215℃
• Boiling Point: 632.3°Cat760mmHg
• Flash Point: 336.2°C
• Appearance: /
• Density: 1.73g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID(164394-23-4)
• EPA Substance Registry System: 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID(164394-23-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 164394-23-4(Hazardous Substances Data)

Upstream product

• 118752-27-5 5-Nitro-2,9-dimethyl-1,10-phenanthroline 
• 484-11-7 2.9-dimethyl-1,10-phenanthroline 
• 164394-22-3 5-Nitro-2,9-bis(trichloromethyl)-1,10-phenanthroline 

Relevant articles and documents

A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells

G-quadruplex (G4) DNA structures are implicated in central biological processes and are considered promising therapeutic targets because of their links to human diseases such as cancer. However, functional details of how, when, and why G4 DNA structures form in vivo are largely missing leaving a knowledge gap that requires tailored chemical biology studies in relevant live-cell model systems. Towards this end, we developed a synthetic platform to generate complementary chemical probes centered around one of the most effective and selective G4 stabilizing compounds, Phen-DC3. We used a structure-based design and substantial synthetic devlopments to equip Phen-DC3 with an amine in a position that does not interfere with G4 interactions. We next used this reactive handle to conjugate a BODIPY fluorophore to Phen-DC3. This generated a fluorescent derivative with retained G4 selectivity, G4 stabilization, and cellular effect that revealed the localization and function of Phen-DC3 in human cells. To increase cellular uptake, a second chemical probe with a conjugated cell-penetrating peptide was prepared using the same amine-substituted Phen-DC3 derivative. The cell-penetrating peptide conjugation, while retaining G4 selectivity and stabilization, increased nuclear localization and cellular effects, showcasing the potential of this method to modulate and direct cellular uptake e.g. as delivery vehicles. The applied approach to generate multiple tailored biochemical tools based on the same core structure can thus be used to advance the studies of G4 biology to uncover molecular details and therapeutic approaches. This journal is

Forming a complex compound fluorescent biuranate, synthesis of the same, and method of measuring probe for measuring fluorescent biuranate biuranate

Disclosed is a compound suitable for use as a fluorescent probe for the detection of uranium. The compound enables the qualitative and quantitative analysis of uranium present in waste samples using less expensive apparatuses. The compound of the present invention has the structure shown by the following formula.

Preparation of some new intercalating europium(III) sensitizers

The synthesis of phenanthridinium salts linked to a chelating phenanthroline-2,9-dicarboxylic acid group, as in 1 and 2, is described.These derivatives behave as useful probes for the identification of DNA single strands in a new homogeneous assay.