1644664-80-1

Basic information

• Product Name: N'-(2-furylmethylene)-2-furohydrazide
• Synonyms: N'-(2-furylmethylene)-2-furohydrazide;2-Furancarboxylic acid, (2E)-2-(2-furanylmethylene)hydrazide
• CAS NO: 1644664-80-1
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.18
• Mol File: 1644664-80-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N'-(2-furylmethylene)-2-furohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(2-furylmethylene)-2-furohydrazide(1644664-80-1)
• EPA Substance Registry System: N'-(2-furylmethylene)-2-furohydrazide(1644664-80-1)

Safety Data

• Hazardous Substances Data: 1644664-80-1(Hazardous Substances Data)

Upstream product

• 614-99-3 Ethyl 2-furoate 
• 98-01-1 furfural 
• 3326-71-4 2-furoic acid hydrazide 

Relevant articles and documents

From indole to pyrrole, furan, thiophene and pyridine: Search for novel small molecule inhibitors of bacterial transcription initiation complex formation

The search for small molecules capable of inhibiting transcription initiation in bacteria has resulted in the synthesis of N,N′-disubstituted hydrazines and imine-carbohydrazides comprised of indole, pyridine, pyrrole, furan and thiophene using the respec

Synthesis and investigation of antimicrobial activity of some nifuroxazide analogues

A series of nifuroxazide analogues [(2a-2e)-(10a-10f)] have been synthesized, structurally identified and tested for antimicrobial activity against a panel of bacteria (Gram-positive and Gram-negative) and the yeast-like pathogenic fungus Candida albicans. The most active compound in this series was 4-amino-benzoic acid (5-nitro-furan-2-ylmethylene)-hydrazide (2b) and 2-amino-benzoic acid (5-nitrofuran-2-ylmethylene)-hydrazide (2d). Furthermore, compounds (9a-9g) and (10a-10g) recorded no activity against selected species except compounds (9f) and (10f) suggesting that using furoic hydrazide and the corresponding hydrazide of thiophene did not improve the antimicrobial activities for this type of compounds. Regarding the activity against Candida albicans, all compounds showed no activity with an exception of substituted nitro furan (2a-2d).

Electrosynthesis and screening of novel 1,3,4-oxadiazoles as potent and selective antifungal agents

The electrochemical oxidation of aldehyde-N-aroylhydrazone has been studied in the presence of NaClO4 as supporting electrolyte in MeOH solution using cyclic voltammetry and controlled potential electrolysis. The results indicate that intramolecular cyclization of aldehyde-N-aroylhydrazone has been successfully performed at a platinum electrode in an undivided cell with good yields of the corresponding 1,3,4-oxadiazoles at ambient conditions. The reaction products were characterized by spectroscopic methods and a mechanism was deduced from voltammetry studies. The antifungal activity of the synthesized compounds was evaluated on Fusarium oxysporum, Alternaria solani, Candida albicans and Aspergillus niger. The results revealed that all the synthesized compounds have significant antifungal activity against the tested fungi. Among the synthesized derivatives 7b, 7d, 7g, 7h, 7i, 7j and 7r were found to be the most effective antifungal compounds. The Royal Society of Chemistry 2013.