Hydroaminomethylation of Olefins with Aminomethyltrifluoroborate by Photoredox Catalysis
A photocatalytic hydroaminomethylation of olefins with N-protected aminomethyltrifluoroborates has been developed. This methodology provides a new strategy for the introduction of a primary aminomethyl group onto electron-deficient C=C bonds. This reaction constitutes a facile entry into synthetically useful γ-aminobutyric acid (GABA) derivatives such as baclofen.
Miyazawa, Kazuki,Koike, Takashi,Akita, Munetaka
p. 2749 - 2755
(2016/02/18)
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