- Macrocyclic compounds as inhibitors of viral replication
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The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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- Carbonic anhydrase inhibitors: Inhibition of cytosolic isozymes I and II with sulfamide derivatives
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A novel class of effective CAIs has been identified, starting from a very weak carbonic anhydrase inhibitor (CAI), sulfamide, whose X-ray crystal structure in the adduct with hCA II has recently been reported. A series of N,N-disubstituted- and N-substitu
- Casini, Angela,Winum, Jean-Yves,Montero, Jean-Louis,Scozzafava, Andrea,Supuran, Claudiu T.
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p. 837 - 840
(2007/10/03)
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