16478-52-7

Basic information

• Product Name: 3-METHOXY-2-PYRIDINECARBOXYLIC ACID
• Synonyms: 3-METHOXY-2-PYRIDINECARBOXYLIC ACID;3-METHOXYPICOLINIC ACID;3-methoxypyridine-2-carboxylic acid;2-Carboxy-3-methoxypyridine, 3-Methoxypicolinic acid;2-Pyridinecarboxylicacid,3-Methoxy-
• CAS NO: 16478-52-7
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.14
• Product Categories: Carboxylic Acids;Pyridines;Carboxylic Acids;Heterocycle-Pyridine series
• Mol File: 16478-52-7.mol

Chemical Properties

• Melting Point: 159-160℃ (decomposition)
• Boiling Point: 314.728 °C at 760 mmHg
• Flash Point: 144.143 °C
• Appearance: /
• Density: 1.285 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.05±0.50(Predicted)
• CAS DataBase Reference: 3-METHOXY-2-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-2-PYRIDINECARBOXYLIC ACID(16478-52-7)
• EPA Substance Registry System: 3-METHOXY-2-PYRIDINECARBOXYLIC ACID(16478-52-7)

Safety Data

• Hazardous Substances Data: 16478-52-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Methoxy-2-pyridinecarboxylic acid is used as a synthetic building block for the development of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of diverse compounds with potential therapeutic and pesticidal properties.
Used in Antibacterial and Antifungal Applications:
3-Methoxy-2-pyridinecarboxylic acid is utilized as an antibacterial and antifungal agent due to its inherent properties. It can be incorporated into formulations to combat bacterial and fungal infections, offering a potential alternative to existing treatments.
Used in Materials Science:
In the field of materials science, 3-methoxy-2-pyridinecarboxylic acid is used for the development of organic electronic materials. Its structural features make it a promising candidate for applications in organic electronics, such as organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and organic field-effect transistors (OFETs), where its properties can contribute to improved performance and functionality.

InChI:InChI=1/C7H7NO3/c1-11-5-3-2-4-8-6(5)7(9)10/h2-4H,1H3,(H,9,10)

Upstream product

• 874-24-8 3-hydroxypyridine-2-carboxylic acid 
• 24059-83-4 3-methoxypyridine-2-carboxylic acid methyl ester 

Downstream Products

• 24059-83-4 3-methoxypyridine-2-carboxylic acid methyl ester 
• 1214324-71-6 2-(4-fluorophenyl)-3-methoxypyridine 
• 1575753-38-6 C₁₇H₁₉N₃O₃ 
• 945954-94-9 methyl 6-bromo-3-methoxypyridine-2-carboxylate 
• 1349179-60-7 C₁₈H₁₈BrF₂N₃O₄S 
• 1185845-15-1 C₂₇H₂₉ClN₄O₃ 
• 182954-58-1 C₄₆H₅₉N₉O₁₀ 
• 21625-40-1 3-Methoxy-pyridine-2-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S)-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl]-amide 

Relevant articles and documents

Pyridine - 2 - amide compound and its preparation method, its pharmaceutical composition and use thereof

The invention relates to a pyridine-2-amide compound shown as a general formula I as well as a preparation method, a pharmaceutical composition and use thereof. The compound as an integrase inhibitor is used for preparing medicines for treating diseases mediated by various vetrovirus integrases including HIV-1 (Human Immunodeficiency Virus-1) integrase.

Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction

Currently, three HIV-1 integrase (IN) active site-directed inhibitors are in clinical use for the treatment of HIV infection. However, emergence of drug resistance mutations have limited the promise of a long-term cure. As an alternative, allosteric inhibition of IN activity has drawn great attention and several of such inhibitors are under early stage clinical development. Specifically, inhibitors of IN and the cellular cofactor LEDGF/p75 remarkably diminish proviral integration in cells and deliver a potent reduction in viral replicative capacity. Distinct from the extensively studied 2-(quinolin-3-yl) acetic acid or 1H-indol-3-yl-2-hydroxy-4-oxobut-2-enoic acid chemotypes, this study discloses a new class of selective IN-LEDGF/p75 inhibitors without the carboxylic acid functionality. More significantly, 3-hydroxypicolinamides also show low micromolar inhibition against IN dimerization, providing novel dual IN inhibitors with in vitro therapeutically selective antiviral effect for further development. Finally, our shape-based ROCS pharmacophore model of the 3-hydroxypicolinamide class of compounds provides a new insight into the binding mode of these novel IN-LEDGF/p75 inhibitors.

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold

Systematic SAR studies on the HTS hit pyridine-2-carboxylic acid thiazol-2-ylamide (PACT) analogues revealed that the scaffold of PCAT is indispensable for the inhibition of type I MetAP. For effective inhibition of the enzyme, the most suitable position to modify is the 3-position of the pyridine ring of PCAT, and the best substituents are those containing O or N atoms connected directly with the pyridine ring. These findings provide useful information for the design and discovery of more potent inhibitors of type I MetAPs.