- Decyanation method of nitrile organic compound
-
The invention provides a decyanation method of a nitrile organic compound. The nitrile organic compound shown in a general formula (1), a sodium reagent, crown ether and a proton donor are subjected to decyanation reaction in an organic solvent I to generate an organic compound shown in a general formula (2). According to the method, a Na/15-crown-5/H2O system is adopted, so that nitrile organic matters can be converted into a decyanation product, and the generation of amine byproducts is inhibited. The new method does not need to use liquid ammonia as a solvent, and is safer and more convenient to operate. The required sodium dispersoid is low in price; and the 15-crown-5 can be recycled and repeatedly used. The method has the advantages of good chemical selectivity, wide substrate application range, good functional group compatibility and the like.
- -
-
Paragraph 0087-0090
(2020/02/10)
-
- Reductive Cleavage of Unactivated Carbon-Cyano Bonds under Ammonia-Free Birch Conditions
-
A general protocol for the reductive cleavage of unactivated carbon-cyano bonds in aliphatic nitriles has been achieved under single-electron-transfer conditions using Na/15-crown-5/H2O. Electron is supplied by the electride derived from bench-stable sodium dispersions and recoverable 15-crown-5. H2O provides the proton source and suppresses the reduction of aromatic moieties. Compared with the Na/NH3 electride system generated under traditional Birch conditions, this ammonia-free electride system is more practical and features better reactivity and chemoselectivity for the decyanations of a broad range of aliphatic nitriles.
- An, Jie,Ding, Yuxuan,Luo, Shihui,Ma, Lifu
-
-