165544-31-0 Usage
Uses
Used in Pharmaceutical Industry:
Butanoic acid, 3,3-difluoro-2-hydroxy-, ethyl ester is used as a key intermediate in the synthesis of difluoro keto esters and acids, which serve as serine protease inhibitors. These inhibitors are essential in the development of drugs targeting various diseases, including cancer, inflammation, and coagulation disorders, due to their ability to modulate the activity of serine protease enzymes.
Used in Chemical Synthesis:
In the field of chemical synthesis, Butanoic acid, 3,3-difluoro-2-hydroxy-, ethyl ester is utilized as a building block for the preparation of complex organic molecules and pharmaceutical agents. Its unique structure allows for selective functionalization and modification, making it a valuable component in the creation of novel compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 165544-31-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,5,4 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 165544-31:
(8*1)+(7*6)+(6*5)+(5*5)+(4*4)+(3*4)+(2*3)+(1*1)=140
140 % 10 = 0
So 165544-31-0 is a valid CAS Registry Number.
165544-31-0Relevant articles and documents
Conversion of α-keto esters into β,β-difluoro-α-keto esters and corresponding acids: A simple route to a novel class of serine protease inhibitors
Parisi,Gattuso,Notti,Raymo,Abeles
, p. 5174 - 5179 (2007/10/02)
The preparation of a series of β,β-difluoro-α-keto esters and corresponding acids RCF2COCO2R' (R=Me, Et, i-Pr, Bn, and Ph; R'=Et and H), designed as potential inhibitors of serine proteases, is described. The standard procedure developed consists in the initial formation of an α,α- difluoro ester from an α-keto ester, followed by a simple four-step sequence involving the synthesis of hemiacetal, cyanohydrin, and α-hydroxy ester difluorinated intermediates. This method provides an easy route to β,β- difluoro-α-keto esters and corresponding acids, via 'formal' insertion of a difluoromethylene group between the R substituent and the α-carbonyl group of a generic α-keto ester.
