165669-11-4

Basic information

• Product Name: 1H-Indole-3-carbonitrile, 7-aMino-
• Synonyms: 1H-Indole-3-carbonitrile, 7-aMino-;7-amino-1H-indole-3-carbonitrile
• CAS NO: 165669-11-4
• Molecular Formula: C₉H₇N₃
• Molecular Weight: 157.17198
• Mol File: 165669-11-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-3-carbonitrile, 7-aMino-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carbonitrile, 7-aMino-(165669-11-4)
• EPA Substance Registry System: 1H-Indole-3-carbonitrile, 7-aMino-(165669-11-4)

Safety Data

• Hazardous Substances Data: 165669-11-4(Hazardous Substances Data)

Usage

Derivative of indole

A heterocyclic aromatic organic compound widely used in the synthesis of various pharmaceuticals and agrochemicals

Amino group

Present in the 7-position of the indole ring, making it a key intermediate in the synthesis of many biologically active molecules

Versatile reactivity

Makes it an important building block in organic chemistry

Potential applications

Used in the synthesis of pharmaceuticals, herbicides, and insecticides

Upstream product

• 10553-14-7 7-nitro-1H-indole-3-carboxaldehyde 
• 165669-10-3 3-cyano-7-nitroindole 

Downstream Products

• 1084328-92-6 C₁₀H₅N₃S 
• 247186-94-3 4-amino-N-(3-cyano-1H-indol-7-yl)-benzenesulfonamide 
• 247186-93-2 N-(3-cyano-7-indolyl)-4-nitrobenzenesulfonamide 
• 247186-91-0 4-(3-cyano-1H-indol-7-ylsulfamoyl)-benzoic acid 

Relevant articles and documents

Integrin expression inhibitors

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents.

We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogues examined, ER-35745, a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice.

Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle

Described herein is the discovery of a novel series of antitumor sulfonamides targeting G1 phase of the cell cycle. Cell cycle control in G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins invol