- STABLE NEUTRAL NITRIC OXIDE SOURCE
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C-nitroso compound capable of releasing neutral nitric oxide is made stable by forming a Diels Alder adduct thereof which is functionalized at the Diels-Alder double bond to impart the stability. Treatment of the stabilized adduct with agent that removes functionalization and regenerates Diels Alder double bond triggers delivery of neutral nitric oxide via retro Diels-Alder reaction and homolytic scission.
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Page/Page column 8
(2008/12/08)
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- New NO donors with antithrombotic and vasodilating activities, part 28: N-(1-cyanoalkyl)-N-hydroxyureas
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Nineteen N-(1-cyanoalkyl)-N-hydroxyureas comprising aliphatic (3a-i, 4a, b, and 5a) and aromatic (3j-n, 4c, 5b) compounds were prepared, fourteen of them for the first time, and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Th
- Camehn, Rainer,Rehse, Klaus
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- Azodioxides activated by electron acceptors in geminal or vicinal position
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Twenty-two nitroso compounds with cyano, acyloxy, or carbonyl groups in geminal position were prepared eight of them for the girst time. In the solid state these compounds dimerize to colorless azodioxides. Exceptions arethe 4- nitrobenzoyloxynitroso comp
- Rehse, Klaus,Herpel, Martin
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p. 104 - 110
(2007/10/03)
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