AZIRIDINE-2-PHOSPHONIC ACID, THE VALUABLE SYNTHON FOR SYNTHESIS OF 1-AMINO-2-FUNCTIONALIZED ETHANEPHOSPHONIC ACIDS
The ring-opening of aziridine-2-phosphonic acid with a series of nucleophiles was studied.This reaction was found to proceed regioselectively and to provide a good preparative method for the synthesis of phosphonic analogs of various 2-substituted 1-amino