Rapid and efficient synthesis of 2-amino-4H-benzothiazines
(matrix presented) The benzothiazine nucleus is a relatively unexplored class of compounds, from the standpoint of both synthetic chemistry and biological activity. We have developed a rapid, high-yielding synthesis of benzothiazines in which a precursor
Recyclable glucose-derived palladium(0) nanoparticles as in situ-formed catalysts for cross-coupling reactions in aqueous media
In situ-generated, glucose-derived palladium(0) nanoparticles were shown to be convenient and effective catalysts for aqueous Mizoroki-Heck, Sonogashira and Suzuki-Miyaura cross-coupling reactions. The addition of only 4-10 mol% glucose to the reaction mixture lead to a significant increase in yield of the desired products in comparison to processes that omitted the renewable sugar. Interestingly, the Mizoroki-Heck reaction was observed to proceed in good yield even as the reaction reached acidic pH levels. Extensive analysis of the size and morphology of the in situ-formed palladium nanoparticles using advanced analytical techniques showed that the zero valent metal was surrounded by hydrophilic hydroxyl groups. The increased aqueous phase affinity afforded by these groups allowed for facile recycling of the catalyst.
Camp, Jason E.,Dunsford, Jay J.,Dacosta, Oliver S. G.,Blundell, Rebecca K.,Adams, James,Britton, Joshua,Smith, Robert J.,Bousfield, Thomas W.,Fay, Michael W.
p. 16115 - 16121
(2016/02/20)
RuCl2(PPh3)3/HCOOH/Et3N AS A NEW HYDROGEN SOURCE. SELECTIVE REDUCTION OF AROMATIC NITRO COMPOUNDS CATALYSED BY Pd ON CARBON
Pd on carbon increases the reactivity of the system RuCl2(PPh3)3/HCOOH/Et3N and induces selective reduction of nitroaromatic compounds which is faster than that of olefins or haloaromatic derivatives.Other potentially reducible groups do not react.
Khai, Bui The,Arcelli, Antonio
p. C63 - C66
(2007/10/02)
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