cas 16659-88-4, (+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE | Articles data ｜lookchem

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16659-88-4

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Geranyl derivatives of isoquinoline alkaloids show increased biological activities
Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound. The Japan Institute of Heterocyclic Chemistry.
Nishiyama, Yumi,Iwasa, Kinuko,Okada, Suguru,Takeuchi, Sousuke,Moriyasu, Masataka,Kamigauchi, Miyoko,Koyama, Junko,Takeuchi, Atsuko,Tokuda, Harukuni,Kim, Hye-Sook,Wataya, Yusuke,Takeda, Kazuyoshi,Liu, Yi-Nan,Wu, Pei-Chi,Bastow, Kenneth F.,Akiyama, Toshiyuki,Lee, Kuo-Hsiung
experimental part
p. 1193 - 1229
(2011/04/16)

Expedient synthesis of racemic and optically active N-norreticuline and N-substituted and 6'-bromo-N-norreticulines
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Rice,Brossi
p. 592 - 601
(2007/10/02)

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1232653-32-5
(+/-)-N,N-digeranyltetrahydropapaveroline trifluoroacetate

Chemical Properties

Melting Point: 277 °C (dec.)(lit.)
Boiling Point: 573.2°Cat760mmHg
Flash Point:235.1°C
Density: 1.406g/cm³
Solubility:DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly
Storage Temp.:Amber Vial, Refrigerator
Vapor Pressure: 9.67E-14mmHg at 25°C
PSA: 92.95000
LogP: 3.22540

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