Synthesis of 5- and 6-membered heterocycles by a strategy combining SNAr and SRN1 reactions
The SRN1 mechanism is compatible with many substituents on the benzenic substrate and allows SRN1 reactions to be combined with SNAr reactions in a strategy which brings together their corresponding synthetic advantages.Thus, compounds containing benzene fused to 5- or 6-membered heterocycles containing N (indoles), N and P (benzazaphospholes) and N and S (benzothiazines) are readily obtained. nucleophilic aromatic substitution / SRN1 / SNAr / benzene-fused heterocycles
Beugelmans, Rene,Chbani, Mohamed
p. 306 - 313
(2007/10/02)
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