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METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE is a colorless liquid chemical compound with the molecular formula C11H8F2O2. It is commonly used as a building block in the production of various pharmaceuticals, agrochemicals, and organic compounds. Known for its high reactivity, it is a key component in the synthesis of complex organic compounds and is also used in the manufacturing of polymers and plastics.

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  • 166883-00-7 Structure
  • Basic information

    1. Product Name: METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE
    2. Synonyms: METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE;3-(2,4-DIFLUOROPHENYL)-ACRYLIC ACID METHYL ESTER;3-(2,4-DIFLUOROPHENYL)-2-PROPENOIC ACID METHYL ESTER;(E)-Methyl 3-(2,4-Difluorophenyl)Acrylate;Methyl 3-(2,4-difluorophenyl)
    3. CAS NO:166883-00-7
    4. Molecular Formula: C10H8F2O2
    5. Molecular Weight: 198.17
    6. EINECS: N/A
    7. Product Categories: pharmacetical
    8. Mol File: 166883-00-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 244.5°Cat760mmHg
    3. Flash Point: 98.8°C
    4. Appearance: /
    5. Density: 1.247g/cm3
    6. Vapor Pressure: 0.0302mmHg at 25°C
    7. Refractive Index: 1.523
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE(166883-00-7)
    12. EPA Substance Registry System: METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE(166883-00-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 166883-00-7(Hazardous Substances Data)

166883-00-7 Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE is used as a building block for the production of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE is used as a building block for the production of agrochemicals, aiding in the development of effective crop protection products.
Used in Organic Compounds Synthesis:
METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE is used as a key component in the synthesis of complex organic compounds, playing a crucial role in the creation of various chemical products.
Used in Polymer and Plastics Manufacturing:
METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE is used in the manufacturing of polymers and plastics, contributing to the development of new materials with specific properties.
It is important to handle METHYL 3-(2,4-DIFLUOROPHENYL)ACRYLATE with caution, as it can be hazardous if not properly used and stored.

Check Digit Verification of cas no

The CAS Registry Mumber 166883-00-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,8,8 and 3 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 166883-00:
(8*1)+(7*6)+(6*6)+(5*8)+(4*8)+(3*3)+(2*0)+(1*0)=167
167 % 10 = 7
So 166883-00-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H8F2O2/c1-14-10(13)5-3-7-2-4-8(11)6-9(7)12/h2-6H,1H3/b5-3+

166883-00-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-Methyl 3-(2,4-Difluorophenyl)Acrylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:166883-00-7 SDS

166883-00-7Downstream Products

166883-00-7Relevant articles and documents

6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL

-

Paragraph 0377; 0379, (2018/04/13)

The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

Palladium nanoparticles supported on a titanium dioxide cellulose composite (PdNPs@TiO2-Cell) for ligand-free carbon-carbon cross coupling reactions

Jadhav, Sanjay,Jagdale, Ashutosh,Kamble, Santosh,Kumbhar, Arjun,Salunkhe, Rajshri

, p. 3406 - 3420 (2016/01/25)

Well-dispersed non-spherical PdNPs with a diameter of 39-45 nm supported on a TiO2-cellulose composite (PdNPs@TiO2-Cell) can be synthesized by a simple and clean route. The catalyst was well characterized by XRD, FE-SEM, EDS, and TEM techniques. The PdNPs have good dispersity on the TiO2-Cell support. This results in excellent catalytic activities for the synthesis of biphenyls, acrylates, acetylenes and prochiral ketones using low Pd loading (1 mol%) at comparatively low temperature. The effects of the nature and amount of bases, nature of solvents, amount of catalyst and the reaction temperature on the activity of PdNPs@TiO2-Cell were thoroughly investigated. The catalyst showed at least four times reusability without decrease in catalytic activity.

NRF2 REGULATORS

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Page/Page column 314; 315, (2017/01/02)

Provided are aryl analogs,pharmaceutical compositions containing them and their use as NRF2 regulators.

NRF2 REGULATORS

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Page/Page column 566, (2015/07/07)

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.

Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans

Lansdell, Mark I.,Hepworth, David,Calabrese, Andrew,Brown, Alan D.,Blagg, Julian,Burring, Denise J.,Wilson, Peter,Fradet, David,Brown, T. Bruce,Quinton, Faye,Mistry, Neela,Tang, Kim,Mount, Natalie,Stacey, Peter,Edmunds, Nick,Adams, Cathryn,Gaboardi, Samantha,Neal-Morgan, Stevie,Wayman, Chris,Cole, Susan,Phipps, Joanne,Lewis, Mark,Verrier, Hugh,Gillon, Val,Feeder, Neil,Heatherington, Anne,Sultana, Stefan,Haughie, Scott,Martin, Steven W.,Sudworth, Maria,Tweedy, Sarah

scheme or table, p. 3183 - 3197 (2010/09/15)

The relevance of the melanocortin system to sexual activity is well established, and nonselective peptide agonists of the melanocortin receptors have shown evidence of efficacy in human sexual dysfunction. The role of the MC4 receptor subtype has received particular scrutiny, but the sufficiency of its selective activation in potentiating sexual response has remained uncertain owing to conflicting data from studies in preclinical species. We describe here the discovery of a novel series of small-molecule MC4 receptor agonists derived from library hit 2. The addition of methyl substituents at C3 and C5 of the 4-phenylpiperidin-4-ol ring was found to be markedly potency-enhancing, enabling the combination of low nanomolar potencies with full rule-of-five compliance. In general, the series shows only micromolar activity at other melanocortin receptors. Our preferred compound 40a provided significant systemic exposure in humans on both sublingual and oral administration and was safe and well tolerated up to the maximum tested dose. In a pilot clinical study of male erectile dysfunction, the highest dose of 40a tested (200 mg) provided a similar level of efficacy to sildenafil.

Pharmaceutically active compounds

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Page/Page column 65, (2010/02/13)

The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein and especially to selective MCR4 agonist compounds, to

ETHER DERIVATIVES HAVING 5-LIPOXYGENASE INHIBITORY ACTIVITY

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, (2008/06/13)

The invention concerns ether derivatives of the formula I Q1?X?Ar?Q2 wherein Q1 is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; X is oxy, thio, sulphinyl or sulphonyl; Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazoiediyl, thiadiazoiediyl or oxadiazolediyl; and Q2 is selected from the groups of the formulae II and III: wherein R1 is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl; R2 is (l-4C)alkyl; and R3 is hydrogen or (l-4C)alkyl; or R2 and R3 are linked to form a methylene, vinylene, ethylene or trimethylene group; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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