cas 16712-58-6, 5-AMINO-2,3-DIMETHYLINDOLE | Articles data ｜lookchem

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16712-58-6

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INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
Methods of treating polyQ diseases or disorders such as Huntington's Disease are presented. Compounds of formula (I) of the disclosure are capable of binding directly to the polyQ segment of mutated huntingtin. This binding results in at least partial rev
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Paragraph 0180

(2021/09/04)

One-pot synthesis of pyrrolo[3,2-f]-and pyrrolo[2,3-h]quinoline derivatives: Observation of an unexpected mechanistic pathway
One-pot synthesis of pyrrolo[3,2-f]- and pyrrolo[2,3-h]quinolines were obtained starting from substituted 5-aminoindoles, benzaldehydes, and phenylacetylenes in the presence of La(OTf)3 as a catalyst in good yields. The indole moiety in 5-aminoindole is believed to be mainly responsible for the observation of unexpected mechanistic pathway to the formation of pyrrolo[2,3-h]quinoline. Georg Thieme Verlag Stuttgart · New York.
Ramesh, Subburethinam,Nagarajan, Rajagopal
supporting information; scheme or table
p. 717 - 722
(2012/07/03)

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Chemical Properties

Melting Point: 178 °C
Boiling Point: 368.3°Cat760mmHg
Flash Point:204.2°C
Density: 1.172g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 1.28E-05mmHg at 25°C
PKA: 18.27±0.30(Predicted)
PSA: 41.81000
LogP: 2.94810

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