167280-87-7

Basic information

• Product Name: 2-Thiophenecarboxylicacid,3-amino-4,5-dihydro-,methylester(9CI)
• Synonyms: 3-Amino-4,5-dihydro-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylicacid,3-amino-4,5-dihydro-,methylester(9CI)
• CAS NO: 167280-87-7
• Molecular Formula: C₆H₉NO₂S
• Molecular Weight: 159.21
• Product Categories: CARBOXYLICESTER
• Mol File: 167280-87-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Thiophenecarboxylicacid,3-amino-4,5-dihydro-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylicacid,3-amino-4,5-dihydro-,methylester(9CI)(167280-87-7)
• EPA Substance Registry System: 2-Thiophenecarboxylicacid,3-amino-4,5-dihydro-,methylester(9CI)(167280-87-7)

Safety Data

• Hazardous Substances Data: 167280-87-7(Hazardous Substances Data)

Upstream product

• 107-13-1 acrylonitrile 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 1427782-89-5 IWP-L₆ 
• 167280-94-6 3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester 
• 167280-96-8 3-Phenyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione 

Relevant articles and documents

Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/?

Inhibitors of Wnt production (IWPs) are known antagonists of the Wnt pathway, targeting the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. Since IWPs show structural similarities to benzimidazol

SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The present invention relates to novel substituted azetidine dihydrothienopyridines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases wi

Unprecedented Demonstration of Regioselective SEAr Reaction giving Unsymmetrical Regioregular Oligothiophenes

Aromatization of 4-cyano-3-oxotetrahydrothiophene by sulfuryl chloride gives the new building block 4-cyano-3-pyrrolidylthiophene, which forms unsymmetrical regioregular oligothiophenes with a strict alternation of the donor and acceptor groups along the conjugated system. The self-coupling reactions that form the oligomers are shown to proceed by a regioselective electrophilic aromatic substitution mechanism involving a stabilized Wheland intermediate. First alternate: Regioregular oligothiophenes based on the 3-pyrrolidyl-4-cyanothiophene building block, with a strict alternation of the donor and acceptor groups along the conjugated backbone, have been prepared in one step. The mechanism of formation of the oligomers corresponds to a regioselective self-electrophilic aromatic substitution (self-SEAr) involving a stabilized Wheland intermediate.

HIGHLY POTENT INHIBITORS OF PORCUPINE

The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

The development of highly potent inhibitors for porcupine

Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and activity. We recently disclosed a class of small molecules (IWPs) as the first reported Porcn inhibitors. We now describe the structure-activity relationship studies and the identification of subnanomolar inhibitors. We also report herein the effects of IWPs on Wnt-dependent developmental processes, including zebrafish posterior axis formation and kidney tubule formation.