167781-50-2

Basic information

• Product Name: 1-CYCLOPROPYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: 1-CYCLOPROPYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;Isoquinoline, 1-cyclopropyl-1,2,3,4-tetrahydro-
• CAS NO: 167781-50-2
• Molecular Formula: C12H15N
• Molecular Weight: 173.25
• Product Categories: Tetrahydroisoquinolines
• Mol File: 167781-50-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CYCLOPROPYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOPROPYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(167781-50-2)
• EPA Substance Registry System: 1-CYCLOPROPYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(167781-50-2)

Safety Data

• Hazardous Substances Data: 167781-50-2(Hazardous Substances Data)

Usage

Heterocyclic compound

It is a compound containing one or more atoms of a different element, such as nitrogen, oxygen, or sulfur, in a ring structure.

Cyclopropane ring

It has a three-membered carbon ring, which is a closed loop of three carbon atoms connected by bonds.

Isoquinoline moiety

It contains a fused bicyclic structure consisting of a six-membered benzene ring and a five-membered nitrogen-containing ring.

Derivative of tetrahydroisoquinoline

It is a modified version of the parent compound tetrahydroisoquinoline, which is a class of compounds with potential biological and pharmacological activities.

Potential biological activities

The compound has been studied for its potential as a ligand for dopamine receptors, which are involved in the regulation of various physiological processes, including mood and cognition.

Antipsychotic and antidepressant agent

It has been investigated for its potential therapeutic effects in treating mental health disorders, such as schizophrenia and depression.

Precursor in synthesis

The compound has been explored as a starting material for the synthesis of other biologically active compounds, which could have various applications in medicine and pharmacology.

Unique structure

Its combination of a cyclopropane ring and an isoquinoline moiety gives it a distinct molecular structure that may contribute to its potential biological activities.

Interest for further research and development

Due to its unique structure and potential biological activities, 1-CYCLOPROPYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is considered a molecule of interest for continued research and development in the fields of chemistry, biology, and pharmacology.

Upstream product

• 886759-42-8 N-formyl-1-cyclopropyl-1,2,3,4-tetrahydroisoquinoline 
• 886759-33-7 N-formyl-1-cyclopropyl-4-phenylsulfanyl-1,2,3,4-tetrahydroisoquinoline 
• 3481-02-5 cyclopropyl phenyl ketone 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 64-04-0 phenethylamine 
• 401582-88-5 N-phenethylcyclopropanecarboxamide 
• 886759-27-9 N-(1-cyclopropyl-1-phenylmethyl)-N-(2-phenylsulfinylethyl)formamide 
• 886759-21-3 N-(1-cyclopropyl-1-phenylmethyl)-N-(2-phenylsulfanylethyl)formamide 
• 886759-15-5 1-cyclopropyl-1-phenylmethyl-(2-phenylsulfanyl)ethylamine 

Relevant articles and documents

Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination

A visible-light-induced/thiourea-mediated intramolecular cyclization of o-nitroarenes under mild conditions is realized for the first time, which provides an efficient and environmentally friendly way to access pharmaceutical relevant quinazolinone derivatives. The reaction can be easily extended to gram level by using a continuous-flow setup with high efficiency. Mechanistic investigation including control experiments, transient fluorescence, UV-vis spectra, and DFT calculations suggests that the formation of active biradical intermediates via intramolecular single electron transfer (SET) is key stage in the catalytic cycle.

Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization

An efficient metal-free, (NH4)2S2O8 mediated intramolecular oxidative cyclization for the construction of polycyclic heterocycles was disclosed. A series of polycyclic quinazolinone derivatives with good functional group tolerance were obtained in high yields. The natural products tryptanthrin and rutaecarpine, as well as their derivatives, were easily synthesized by this strategy. A preliminary mechanism study suggested the carbon-centered radical was involved in the catalytic cycle.

Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells

The synthesis of several 1-alkyl-1,2,3,4-tetrahydroisoquinolines, which may play an important role in Parkinson's disease, has been achieved by modified Pictet-Spengler cyclization of the formyliminium ion. The direct cytotoxicity and preventative effects

Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives

Several 1-alkyl-1,2,3,4-tetrahydroisoquinoline (TIQ) derivatives, which may play a role in Parkinson's disease, have been synthesized via Pummerer-type cyclization of the sulfonium ion formed in situ from N-formyl sulfoxide. Using an in vitro trypan blue

Quinazoline deriviates for treating peptic ulcer

A quinazoline derivative represented by formula(I) or a pharmaceutically acceptable salt thereof is useful for the treatment of peptic ulcer, wherein: STR1 R1 and R2 are each hydrogen or a C1 -C4 alkyl group; R3 is hydrogen or a halogen; R4, R5, R6, R7, R8 and R9, which may be the same or different, are each hydrogen, a C1 -C4 alkyl group, a cyclopropyl group, or a C1 -C4 alkyl group substituted with a halogen; and R10 is a methoxy group.