- Preparation method and application of novel photosensitizer
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The invention relates to a preparation method and application of a novel photosensitizer. The photosensitizer is synthesized for the first time. A general formula compound represented by an intermediate formula (I) is used as a mother core, and is subjected to a Knoevenagel reaction with 4-hydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde and 3,5-diiodo-4-hydroxybenzaldehyde to obtain the general formula photosensitizer represented by a formula (II). The method creatively reserves functional groups (R1, R2) on the intermediate formula (I) and the photosensitizer formula (II), and synthesizes the intermediate and the photosensitizer with S and Se as central atoms (Q) for the first time. The novel photosensitizer provided by the invention solves the technical problems that an existing photosensitizer has a narrow absorption range, a poor therapeutic effect in the visible light range, excessive power of a used light source, and inability to introduce functional groups.
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Paragraph 0022; 0032; 0034
(2020/02/14)
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- Synthesis of 2-polyfluoroalkylated thiochromones and chromones
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A number of 2-(polyfluoroalkyl)-thiochromones (4) and -chromones (5) have been synthesized in good to excellent yield by an intramolecular Friedel-Crafts acylation of the Z isomers of 3-(arylthio)- (2) and 3-(aryloxy)polyfluoro-2-alkenoic acids (3), which
- Tamura, Kazushige,Ishihara, Takashi,Yamanaka, Hiroki
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- Synthesis of 2H-1-Benzothiopyran-2-ones (Thiocoumarins) and Related Compounds from Benzenethiols and Diketene
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The products formed by the reaction of benzenethiols with diketene in the presence of H2SO4 are (E)-β-(arylthio)crotonic acids (2) and/or isomeric (Z)-β-(arylthio)crotonic acids and not, as has been reported, S-phenyl-3-oxobutanethioates (1).Compounds 1a-k, as the precursor of thiocoumarins, were prepared from benzenethiols and diketene in the presence of triethylamine.The reaction of 1 with various condensing agents has been examined to prepare 2H-1-benzothiopyran-2-ones (thiocoumarins).It is found that 4-methyl(thiocoumarins) were conveniently prepared by thereaction of 1 with anhydrous aluminium chloride in yields of 16-48percent.When 1 was treated with PPA, isomeric 2-methyl(thiochromones) were preferentially obtained in yields of 5-66percent, and compound 2 was isolated as an intermediate.The spectral characteristics of 4-methyl(thiocoumarins) have also been described.
- Nakazumi, Hiroyuki,Asada, Akira,Kitao, Teijiro
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p. 2046 - 2049
(2007/10/02)
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