Annelated pyrrolo-pyrimidines from amino-cyanopyrroles and BMMAs as leads for new DNA-interactive ring systems
The efficient one-pot synthesis of several new tricyclic systems of type 1 and 2, obtained from the reaction of substituted 2-amino-3-cyanopyrroles and 3-amino-4-cyanopyrroles with BMMAs, is reported. The duration and yields of the reaction strongly depen
Lauria, Antonino,Bruno, Marcella,Diana, Patrizia,Barraja, Paola,Montalbano, Alessandra,Cirrincione, Girolamo,Dattolo, Gaetano,Almerico, Anna Maria
Synthesis of condensed pyrimidines in one-pot reaction from pyranoquinolines and BMMAs
New pentacyclic heterocycles of the type 3a-e -5a-e were synthesized by one - pot reaction of the amino-cyano pyrano[3,2-h]quinolines la-e with BMMAs ( e.g. Ethyl N-[bis (methylsulfanyl) methylene] glycinate, ethyl 2[bis (methylsulfanyl) methylene]-1-methylhydrazine carboxylate and / or ethyl N[bis(methylsulfanyl) methylene]- ss-alaninate). All the synthesized derivatives were identified by conventional methods (IR, 1HNMR, MS) and elemental analysis. Antifungal tests were also performed.
Nahas, Nariman M.
p. 51 - 54
(2008/09/19)
N-AMINO ESTERS (BMMA): NOVEL REAGENTS FOR ANNELATION OF PYRIMIDINE MOIETIES
New reagents for heterocyclic annelations containing a N-amino moiety (=BMMA) were developed and studied regarding their scope and limitations: one-pot reaction with (hetero)aromatic ortho-aminocarbonyl-type model compounds ("car
Sauter, Fritz,Froehlich, Johannes,Blasl, Karin,Gewald, Karl
p. 851 - 866
(2007/10/02)
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