168473-87-8

Basic information

• Product Name: ETHYL 4-BROMO-3-NITROBENZOATE
• Synonyms: 4-Bromo-3-nitro-benzoic acid ethyl ester
• CAS NO: 168473-87-8
• Molecular Formula: C₉H₈BrNO₄
• Molecular Weight: 274.07
• Mol File: 168473-87-8.mol

Chemical Properties

• Boiling Point: 333.9 °C at 760 mmHg
• Flash Point: 155.7 °C
• Appearance: /
• Density: 1.594 g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4-BROMO-3-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-BROMO-3-NITROBENZOATE(168473-87-8)
• EPA Substance Registry System: ETHYL 4-BROMO-3-NITROBENZOATE(168473-87-8)

Safety Data

• Hazardous Substances Data: 168473-87-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 4-BROMO-3-NITROBENZOATE is used as a chemical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 4-BROMO-3-NITROBENZOATE is utilized as an intermediate in the production of agrochemicals. Its involvement in this industry is essential for the creation of compounds that can protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
ETHYL 4-BROMO-3-NITROBENZOATE is used as a building block in organic synthesis. It is particularly instrumental in the production of esters and other organic compounds, which have a wide range of applications across different industries.

InChI:InChI=1/C9H8BrNO4/c1-2-15-9(12)6-3-4-7(10)8(5-6)11(13)14/h3-5H,2H2,1H3

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 

Downstream Products

• 861306-79-8 3-nitro-4-phenoxy-benzoic acid ethyl ester 
• 76918-64-4 ethyl 4-amino-3-nitrobenzoate 
• 355425-79-5 4-hydrazino-3-nitro-benzoic acid ethyl ester 
• 16588-18-4 ethyl 3-nitro-4-(phenylamino)benzoate 
• 100871-16-7 (4-ethoxycarbonyl-2-nitro-phenyl)-cyano-acetic acid ethyl ester 
• 78914-77-9 3,3'-azodibenzenemethanol 
• 1335114-88-9 C₁₈H₂₄N₂O₈ 
• 168473-88-9 3-amino-4-bromobenzoic acid ethyl ester 

Relevant articles and documents

The Suzuki–Miyaura Cross-Coupling as the Key Step in the Synthesis of 2-Aminobiphenyls and 2,2'-Diaminobiphenyls: Application in the Synthesis of Schiff Base Complexes of Zn

2-Nitrophenylboronic acids serve as interesting starting materials for the construction of biphenyl- and terphenyl-based amines if subjected to the Suzuki–Miyaura reaction. Unfortunately, these boronic acids suffer from low reactivity in Suzuki reactions, alongside their low stability in the presence of Pd. Herein, a general method for the construction of 2-nitro-substituted bi- and terphenyls is presented, with special emphasis on the synthesis of 2-amino-2'-nitrobi- and terphenyls. Comparisons are made with other boronic acids that have some of the aforementioned issues. Finally, the application of the obtained 2-amino-2'-nitrobi- and terphenyls as starting materials for the synthesis of bi- and terphenyl based di- and triamines is encountered for, with emphasis on the use of these amines as precursors for Schiff base ligands. In addition, the synthesis of some Zn complexes of these ligands is presented.

SUBSTITUTED 1,2,4-TRIAZOLIN-3-ONE COMPOUNDS BEARING ACIDIC FUNCTIONAL GROUPS AS BALANCED ANGIOTENSIN II ANTAGONISTS

Novel substituted 1,2,4-triazolin-3-ones of the formula (I) are useful as angiotensin II antagonists. STR1