168542-35-6

Basic information

• Product Name: 7-METHYL-8-OXO-5-PHENYL-7,8-DIHYDRO-1,7-NAPHTHYRIDINE-6-CARBOXYLIC ACID
• Synonyms: 7-METHYL-8-OXO-5-PHENYL-7,8-DIHYDRO-1,7-NAPHTHYRIDINE-6-CARBOXYLIC ACID;7,8-dihydro-7-methyl-8-oxo-5-phenyl-1,7-Naphthyridine-6-carboxylic acid;7-Methyl-8-oxo-5-phenyl-1,7-naphthyridine-6-carboxylic acid
• CAS NO: 168542-35-6
• Molecular Formula: C16H12N2O3
• Molecular Weight: 280.282
• Mol File: 168542-35-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-METHYL-8-OXO-5-PHENYL-7,8-DIHYDRO-1,7-NAPHTHYRIDINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-8-OXO-5-PHENYL-7,8-DIHYDRO-1,7-NAPHTHYRIDINE-6-CARBOXYLIC ACID(168542-35-6)
• EPA Substance Registry System: 7-METHYL-8-OXO-5-PHENYL-7,8-DIHYDRO-1,7-NAPHTHYRIDINE-6-CARBOXYLIC ACID(168542-35-6)

Safety Data

• Hazardous Substances Data: 168542-35-6(Hazardous Substances Data)

Upstream product

• 168542-37-8 3-benzoyl-N-<(benzyloxycarbonyl)methyl>-N-methyl-2-pyridinecarboxamide 
• 170640-01-4 3-benzoyl-N-(cyanomethyl)-N-methyl-2-pyridinecarboxamide 
• 170640-04-7 3-benzoyl-N-(formylmethyl)-N-methyl-2-pyridinecarboxamide 
• 170640-02-5 7,8-dihydro-7-methyl-8-oxo-5-phenyl-6-pyrido<3,4-b>pyridinecarbonitrile 
• 876487-64-8 3-benzoyl-pyridine-2-carbonyl chloride 
• 168542-38-9 benzyl 7,8-dihydro-7-methyl-8-oxo-5-phenyl-6-pyrido<3,4-b>pyridinecarboxylate 
• 170640-03-6 7,8-dihydro-7-methyl-8-oxo-5-phenyl-6-pyrido<3,4-b>pyridinecarboxamide 
• 170640-06-9 7,8-dihydro-7-methyl-8-oxo-5-phenyl-6-pyrido<3,4-b>pyridinecarboxaldehyde 

Relevant articles and documents

Heterocyclic compounds, their production and use as tachykinin reactor antagonists

A novel compound represented by the formula: STR1 wherein Ring A and Ring B respectively stands for an optionally substituted homo- or hetero-cyclic ring, and at least one of them stands for an optionally substituted heterocyclic ring stand; Ring C stands for an optionally substituted benzene ring; R stands for a hydrogen atom or an optionally substituted hydrocarbon residue; one of X and Y stands for --NR1 -- (R1 stands for a hydrogen atom or an optionally substituted hydrocarbon residue) or --O--, and the other stands for--CO-- or --CS--, or one of them stands for --N= and the other stands for =CR2 -- (R2 stands for a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon residue, an optionally substituted amino group or an optionally substituted hydroxyl group); n denotes 1 or 2 or salts thereof which have an excellent tachykinin receptor antagonistic action and inhibitory action on plasma extravasation.

Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyridopyridine

A series of 4-phenylisoquinolone derivatives were synthesized and evaluated for NK1 (substance P) antagonist activity.Highly potent antagonists, 4-phenyl-3-isoquinolone-N-benzylcarboxamides (11), were discovered from the structure-activity relationship studies on the isoquinolone-urea lead 1a.Optimization of the activity in this series resulted in the development of 5-phenyl-6-pyridopyridine-N-benzylcarboxamides (30) which are highly potent orally active NK1 antagonists.Among the compounds synthesized, N--7,8-dihydro-N,7-dimethyl-8-oxo-5-(substituted phenyl)-6-pyridopyridinecarboxamides (30a,f,g) showed excellent antagonist activities with IC50 values (in vitro inhibition of 125I>BH-SP binding in human IM-9-cells) of 0.21-0.34 nM and ED50 values (in vivo inhibition of capsaicin-induced plasma extravasation in guinea-pig trachea, iv) of 0.017-0.030 mg/kg.These compounds exhibited significantly potent activity upon oral adiministration with ED50 values of 0.068-0.17 mg/kg.Conformational studies on 30g indicated that the two stable conformers of 30g are quite similar to those of CP-99,994.